Display options
Cite
Bühler TA, Bruyère T, Went DF, et al. Rabbit beta-casein promoter directs secretion of human interleukin-2 into the milk of transgenic rabbits. Biotechnology (N Y). 1990;8(2):140-3doi: 10.1038/nbt0290-140.
Bühler, T. A., Bruyère, T., Went, D. F., Stranzinger, G., & Bürki, K. (1990). Rabbit beta-casein promoter directs secretion of human interleukin-2 into the milk of transgenic rabbits. Bio/technology (Nature Publishing Company), 8(2), 140-3. https://doi.org/10.1038/nbt0290-140
Bühler, T A, et al. "Rabbit beta-casein promoter directs secretion of human interleukin-2 into the milk of transgenic rabbits." Bio/technology (Nature Publishing Company) vol. 8,2 (1990): 140-3. doi: https://doi.org/10.1038/nbt0290-140
Bühler TA, Bruyère T, Went DF, Stranzinger G, Bürki K. Rabbit beta-casein promoter directs secretion of human interleukin-2 into the milk of transgenic rabbits. Biotechnology (N Y). 1990 Feb;8(2):140-3. doi: 10.1038/nbt0290-140. PMID: 1366359.
Copy Download .nbib Format: NLM
Share it on

Biotechnology (N Y). 1990 Feb;8(2):140-3. doi: 10.1038/nbt0290-140.

Rabbit beta-casein promoter directs secretion of human interleukin-2 into the milk of transgenic rabbits.

Bio/technology (Nature Publishing Company)

T A Bühler, T Bruyère, D F Went, G Stranzinger, K Bürki

Affiliations

  1. Swiss Federal Institute of Technology Zürich, Institute for Animal Science, Basel.

PMID: 1366359 DOI: 10.1038/nbt0290-140

Abstract

To test the potential usefulness of transgenic rabbits as production systems for human proteins of pharmaceutical value, we cloned the rabbit beta-casein promoter and fused it to the genomic sequence of the human interleukin-2 (hIL2) gene. Four transgenic female rabbits were tested for expression and biological activity of the foreign protein in their milk. The milk of all four females proved to contain biologically active hIL2. The results show that transgenic rabbits may represent a convenient and economic system for the rapid production of biologically active protein in milk.

Similar articles

[No authors listed]
Br Med J. 1898 Mar 19;1(1942):784.
PMID: 20757720

Substances

MeSH terms

Publication Types

LinkOut - more resources