Display options
Cite
Tanaka N, Nishisho I, Yamamoto M, et al. Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma. Genes Chromosomes Cancer. 1992;5(4):399-403doi: 10.1002/gcc.2870050416.
Tanaka, N., Nishisho, I., Yamamoto, M., Miya, A., Shin, E., Karakawa, K., Fujita, S., Kobayashi, T., Rouleau, G. A., & Mori, T. (1992). Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma. Genes, chromosomes & cancer, 5(4), 399-403. https://doi.org/10.1002/gcc.2870050416
Tanaka, N, et al. "Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma." Genes, chromosomes & cancer vol. 5,4 (1992): 399-403. doi: https://doi.org/10.1002/gcc.2870050416
Tanaka N, Nishisho I, Yamamoto M, Miya A, Shin E, Karakawa K, Fujita S, Kobayashi T, Rouleau GA, Mori T. Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma. Genes Chromosomes Cancer. 1992 Nov;5(4):399-403. doi: 10.1002/gcc.2870050416. PMID: 1283329.
Copy Download .nbib Format: NLM
Share it on
Full text links
Wiley

Genes Chromosomes Cancer. 1992 Nov;5(4):399-403. doi: 10.1002/gcc.2870050416.

Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma.

Genes, chromosomes & cancer

N Tanaka, I Nishisho, M Yamamoto, A Miya, E Shin, K Karakawa, S Fujita, T Kobayashi, G A Rouleau, T Mori

Affiliations

  1. Second Department of Surgery, Osaka University Medical School, Japan.

PMID: 1283329 DOI: 10.1002/gcc.2870050416

Abstract

To identify the putative common deleted region on the long arm of chromosome 22 in pheochromocytoma, restriction fragment length polymorphism analysis was performed in 17 pheochromocytomas. All cases were heterozygous for at least one of the eight marker loci on 22q. Loss of heterozygosity (LOH) was observed in nine pheochromocytomas, of which eight were hereditary and one nonhereditary. Three pheochromocytomas had interstitial deletions that enabled us to localize the commonly deleted region as distal to D22S10 and proximal to D22S22. Hereditary pheochromocytoma frequently occurs in association with medullary thyroid carcinoma (MTC). Therefore, we also studied allelic loss on 22q in 23 hereditary MTCs. Only one of the MTCs showed LOH on 22q. Recent studies have mapped tumor suppressor loci associated with meningioma and neurofibromatosis type 2 (NF2) to 22q. The commonly deleted region in pheochromocytoma found by us encompasses the regions to which tumor suppressor genes associated with NF2 and meningioma have been mapped. The exact role of the pheochromocytoma tumor suppressor gene on 22q and its relationship to the suppressor genes involved in NF2 and meningioma remain unknown.

Similar articles

Cited by

Williams MD, Ma J, Grubbs EG, Gagel RF, Bagheri-Yarmand R.
Am J Cancer Res. 2021 Jun 15;11(6):3227-3239. eCollection 2021.
PMID: 34249457

Substances

MeSH terms

Publication Types

LinkOut - more resources