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Nakamura T, Ebihara I, Nagaoka I, et al. Abnormal regulation of insulin-like growth factor gene expression in peripheral blood mononuclear cells from patients with IgA nephropathy. Am J Nephrol. 1992;12(5):292-302doi: 10.1159/000168463.
Nakamura, T., Ebihara, I., Nagaoka, I., Takahashi, T., Tomino, Y., & Koide, H. (1992). Abnormal regulation of insulin-like growth factor gene expression in peripheral blood mononuclear cells from patients with IgA nephropathy. American journal of nephrology, 12(5), 292-302. https://doi.org/10.1159/000168463
Nakamura, T, et al. "Abnormal regulation of insulin-like growth factor gene expression in peripheral blood mononuclear cells from patients with IgA nephropathy." American journal of nephrology vol. 12,5 (1992): 292-302. doi: https://doi.org/10.1159/000168463
Nakamura T, Ebihara I, Nagaoka I, Takahashi T, Tomino Y, Koide H. Abnormal regulation of insulin-like growth factor gene expression in peripheral blood mononuclear cells from patients with IgA nephropathy. Am J Nephrol. 1992;12(5):292-302. doi: 10.1159/000168463. PMID: 1283288.
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S. Karger AG, Basel, Switzerland

Am J Nephrol. 1992;12(5):292-302. doi: 10.1159/000168463.

Abnormal regulation of insulin-like growth factor gene expression in peripheral blood mononuclear cells from patients with IgA nephropathy.

American journal of nephrology

T Nakamura, I Ebihara, I Nagaoka, T Takahashi, Y Tomino, H Koide

Affiliations

  1. Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.

PMID: 1283288 DOI: 10.1159/000168463

Abstract

We investigated insulin-like growth factor (IGF)-I and -II mRNA expression in peripheral blood mononuclear cells (PBMC) and T cells obtained from 31 patients with IgA nephropathy (IgAN), 43 patients with other types of glomerulonephritis and 16 health age-matched controls. The majority of patients with IgAN showed elevated IGF-I and -II mRNA expression in PBMC, while no IGF-I and -II mRNA expression was detected in PBMC obtained from patients with other types of glomerulonephritis or normal controls. In T cells obtained from IgAN, other types of glomerulonephritis and normal controls, however, IGF-I and -II mRNA expression was not detected. A positive correlation was noted between IGF-I and -II mRNA levels and urinary protein excretion. IGF-I and -II mRNA expression also correlated with the histopathological findings in the renal tissue of patients with IgAN. Sixty-nine percent of patients with more than 1.0 g/day proteinuria showed strong [more than (++)] IGF-I and -II mRNA expression in their PBMC. Eighty-one and 76% of patients with grade III and IV histopathological findings, respectively, showed strong IGF-I and -II gene expression in their PBMC. We also studied the clinical course of 11 patients with IgAN during hospitalization. The IGF-I and -II mRNA levels in these patients decreased gradually, as did proteinuria, after treatment. These studies suggest that abnormal regulation of IGF-I and -II gene expression in PBMC may be associated with the progression of IgAN and may be useful as an indicator of disease activity.

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