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Cinca J, Worner F, Carreño A, et al. Reperfusion arrhythmias after chronic regional denervation of the ischaemic myocardium in pigs. Cardiovasc Res. 1992;26(10):962-7doi: 10.1093/cvr/26.10.962.
Cinca, J., Worner, F., Carreño, A., Bardají, A., Salas-Caudevilla, A., & Soler-Soler, J. (1992). Reperfusion arrhythmias after chronic regional denervation of the ischaemic myocardium in pigs. Cardiovascular research, 26(10), 962-7. https://doi.org/10.1093/cvr/26.10.962
Cinca, J, et al. "Reperfusion arrhythmias after chronic regional denervation of the ischaemic myocardium in pigs." Cardiovascular research vol. 26,10 (1992): 962-7. doi: https://doi.org/10.1093/cvr/26.10.962
Cinca J, Worner F, Carreño A, Bardají A, Salas-Caudevilla A, Soler-Soler J. Reperfusion arrhythmias after chronic regional denervation of the ischaemic myocardium in pigs. Cardiovasc Res. 1992 Oct;26(10):962-7. doi: 10.1093/cvr/26.10.962. PMID: 1486589.
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Cardiovasc Res. 1992 Oct;26(10):962-7. doi: 10.1093/cvr/26.10.962.

Reperfusion arrhythmias after chronic regional denervation of the ischaemic myocardium in pigs.

Cardiovascular research

J Cinca, F Worner, A Carreño, A Bardají, A Salas-Caudevilla, J Soler-Soler

Affiliations

  1. Laboratorio de Cardiología Experimental, Hospital General Universitari Vall d'Hebrón, Barcelona, Spain.

PMID: 1486589 DOI: 10.1093/cvr/26.10.962

Abstract

OBJECTIVE: The aim was to assess the effects of chronic regional denervation of the ischaemic myocardium on reperfusion arrhythmias in a model with sparse coronary collateral circulation.

METHODS: Baseline ventricular refractoriness and epicardial activation times were measured together with reperfusion arrhythmias after 15 min (I-15') or 30 min (I-30') of left anterior descending coronary artery occlusion in 38 barbiturate anaesthetised open chest pigs. Twenty pigs (11 in I-15' and nine in I-30') had a chronic (two week) denervation of the left anteroseptal region, whereas 18 pigs (10 in I-15' and eight in I-30') were sham operated (non-denervated) controls. Denervation was induced by pericoronary application of phenol and verified by absence of adrenergic histofluorescence.

RESULTS: As compared with controls, denervated pigs showed: (1) longer activation times: 20.3 (SD 5.2) ms v 16.5 (4.6) ms, p < 0.001; (2) slightly longer refractory periods: 348(28) ms v 334(27) ms; (3) a tendency to lower postreperfusion ectopic activity: ectopic beats divided by time free of ventricular tachycardia: 0.13(0.19) v 0.34(0.40) in I-15', and 0.21(0.24) v 0.39(0.44) in I-30'; (4) slower ventricular tachycardia in I-30': 140(29) beats.min-1 v 185(29) beats.min-1, p < 0.009; and (5) comparable incidence of postreperfusion ventricular fibrillation: 4/11 pigs v 2/10 in I-15', and 5/9 v 4/8 in I-30'.

CONCLUSIONS: Selective chronic denervation of the ischaemic myocardium was unable to protect against malignant reperfusion arrhythmias in hearts with human-like coronary collaterals. This was confirmed at two ischaemic periods known to produce progressive catecholamine accumulation and increased adrenoceptor density in the ischaemic myocardium.

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