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Craft AW, Parker L, Dale G, et al. A pilot study of screening for neuroblastoma in the north of England. Am J Pediatr Hematol Oncol. 1992;14(4):337-41
Craft, A. W., Parker, L., Dale, G., McGill, A. C., Seviour, J. A., Bell, S., Cole, M., & Smith, J. (1992). A pilot study of screening for neuroblastoma in the north of England. The American journal of pediatric hematology/oncology, 14(4), 337-41.
Craft, A W, et al. "A pilot study of screening for neuroblastoma in the north of England." The American journal of pediatric hematology/oncology vol. 14,4 (1992): 337-41.
Craft AW, Parker L, Dale G, McGill AC, Seviour JA, Bell S, Cole M, Smith J. A pilot study of screening for neuroblastoma in the north of England. Am J Pediatr Hematol Oncol. 1992 Nov;14(4):337-41. PMID: 1456400.
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Am J Pediatr Hematol Oncol. 1992 Nov;14(4):337-41.

A pilot study of screening for neuroblastoma in the north of England.

The American journal of pediatric hematology/oncology

A W Craft, L Parker, G Dale, A C McGill, J A Seviour, S Bell, M Cole, J Smith

Affiliations

  1. Department of Child Health, University of Newcastle Upon Tyne, England.

PMID: 1456400

Abstract

A pilot study has been carried out to assess the feasibility of screening for neuroblastoma in 6-month-old infants in the north of England. A total of 20,829 infants were screened. Two true-positive cases were found, along with eight false-positive and three false-negative cases. It was shown that the concentrations of catecholamine metabolites in the urine are dependent on the creatinine content; centiles have been established to allow this relationship to be taken into account. Five of the eight false-positive cases would have been correctly assessed as normal if the new centiles had been used. Preliminary results lend support to the need for a well-designed study of neuroblastoma screening to be carried out, with death from this disease as the only end point.

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