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Hangartner L, Senn BM, Ledermann B, et al. Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies. Proc Natl Acad Sci U S A. 2003;100(22):12883-8doi: 10.1073/pnas.2135542100.
Hangartner, L., Senn, B. M., Ledermann, B., Kalinke, U., Seiler, P., Bucher, E., Zellweger, R. M., Fink, K., Odermatt, B., Bürki, K., Zinkernagel, R. M., & Hengartner, H. (2003). Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies. Proceedings of the National Academy of Sciences of the United States of America, 100(22), 12883-8. https://doi.org/10.1073/pnas.2135542100
Hangartner, Lars, et al. "Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies." Proceedings of the National Academy of Sciences of the United States of America vol. 100,22 (2003): 12883-8. doi: https://doi.org/10.1073/pnas.2135542100
Hangartner L, Senn BM, Ledermann B, Kalinke U, Seiler P, Bucher E, Zellweger RM, Fink K, Odermatt B, Bürki K, Zinkernagel RM, Hengartner H. Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12883-8. doi: 10.1073/pnas.2135542100. Epub 2003 Oct 20. PMID: 14569006; PMCID: PMC240713.
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Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12883-8. doi: 10.1073/pnas.2135542100. Epub 2003 Oct 20.

Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies.

Proceedings of the National Academy of Sciences of the United States of America

Lars Hangartner, Beatrice M Senn, Birgit Ledermann, Ulrich Kalinke, Peter Seiler, Etienne Bucher, Raphaël M Zellweger, Katja Fink, Bernhard Odermatt, Kurt Bürki, Rolf M Zinkernagel, Hans Hengartner

Affiliations

  1. Institute of Experimental Immunology, Department of Pathology, University Hospital, CH-8091 Zurich, Switzerland. [email protected]

PMID: 14569006 PMCID: PMC240713 DOI: 10.1073/pnas.2135542100

Abstract

Two gene-targeted immunoglobulin heavy chain transgenic mouse strains, TgH(KL25) and TgH(VI10), expressing neutralizing specificities for lymphocytic choriomeningitis virus and vesicular stomatitis virus, respectively, have been generated. Three days after lymphocytic choriomeningitis virus infection, TgH(KL25) mice showed a thymus-independent neutralizing IgM response followed by thymus-dependent (TD) IgG. In contrast, WT mice mounted only a TD IgG response around day 80. These observations indicated that not only structural properties of the virus but also immunological parameters such as the frequency of B cells were indicative for the induction of thymus-independent versus TD Ig responses. Naïve vesicular stomatitis virusspecific Ig heavy chain transgenic mice displayed greatly elevated natural antibody titers. However, despite these high naïve titers, de novo activation of naïve CD4+ T and B cells was not blocked. Therefore, B cells giving rise to natural antibodies do not participate in virus-induced antibody responses.

References

  1. Science. 1999 Dec 10;286(5447):2156-9 - PubMed
  2. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2749-54 - PubMed
  3. J Immunol. 2000 Jun 15;164(12):6296-302 - PubMed
  4. J Exp Med. 2000 Jul 17;192(2):271-80 - PubMed
  5. J Exp Med. 2001 Nov 5;194(9):1349-59 - PubMed
  6. Nat Rev Immunol. 2002 May;2(5):323-35 - PubMed
  7. Eur J Immunol. 2003 Apr;33(4):950-61 - PubMed
  8. J Exp Med. 2003 Apr 7;197(7):845-60 - PubMed
  9. Clin Exp Immunol. 1970 Feb;6(2):313-6 - PubMed
  10. Nature. 1972 Aug 11;238(5363):335-7 - PubMed
  11. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3671-5 - PubMed
  12. Virology. 1983 Oct 15;130(1):247-51 - PubMed
  13. Nature. 1984 Dec 6-12;312(5994):548-51 - PubMed
  14. J Immunol. 1986 Apr 15;136(8):3057-61 - PubMed
  15. Proc Natl Acad Sci U S A. 1986 Apr;83(8):2604-8 - PubMed
  16. J Immunol. 1987 Apr 1;138(7):2278-81 - PubMed
  17. J Virol. 1987 Jun;61(6):1867-74 - PubMed
  18. J Virol. 1988 May;62(5):1803-7 - PubMed
  19. J Virol. 1988 Jun;62(6):2102-6 - PubMed
  20. Exp Cell Biol. 1988;56(4):175-80 - PubMed
  21. Eur J Immunol. 1990 Dec;20(12):2547-54 - PubMed
  22. J Virol Methods. 1991 Jun;33(1-2):191-8 - PubMed
  23. Science. 1993 Nov 19;262(5137):1268-71 - PubMed
  24. Science. 1993 Nov 26;262(5138):1448-51 - PubMed
  25. Nature. 1994 May 5;369(6475):31-7 - PubMed
  26. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1257-61 - PubMed
  27. Eur J Immunol. 1995 Jul;25(7):1888-96 - PubMed
  28. Immunity. 1995 Dec;3(6):747-55 - PubMed
  29. Eur J Immunol. 1995 Dec;25(12):3445-51 - PubMed
  30. J Exp Med. 1996 May 1;183(5):2259-69 - PubMed
  31. Science. 1996 Jun 14;272(5268):1649-52 - PubMed
  32. Nature. 1996 Aug 22;382(6593):726-9 - PubMed
  33. J Immunol. 1996 Oct 1;157(7):3074-80 - PubMed
  34. Immunity. 1996 Dec;5(6):639-52 - PubMed
  35. Immunity. 1997 Mar;6(3):225-33 - PubMed
  36. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6874-9 - PubMed
  37. Immunity. 1997 Dec;7(6):765-75 - PubMed
  38. J Exp Med. 1998 Feb 16;187(4):649-54 - PubMed
  39. J Virol. 1998 Mar;72(3):2253-8 - PubMed
  40. J Immunol. 1997 Dec 15;159(12):5795-801 - PubMed
  41. J Exp Med. 1998 Jul 6;188(1):169-80 - PubMed
  42. J Immunol. 1998 Nov 1;161(9):4634-45 - PubMed
  43. Eur J Immunol. 1998 Oct;28(10):3362-70 - PubMed
  44. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2250-5 - PubMed
  45. J Immunol. 1999 Apr 15;162(8):4406-16 - PubMed
  46. J Immunol. 1999 Apr 15;162(8):4536-41 - PubMed
  47. J Exp Med. 1999 Oct 18;190(8):1165-74 - PubMed

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