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Johnson DM, Erwin ME, Barrett MS, et al. Antimicrobial activity of ten macrolide, lincosamine and streptogramin drugs tested against Legionella species. Eur J Clin Microbiol Infect Dis. 1992;11(8):751-5doi: 10.1007/BF01989985.
Johnson, D. M., Erwin, M. E., Barrett, M. S., Gooding, B. B., & Jones, R. N. (1992). Antimicrobial activity of ten macrolide, lincosamine and streptogramin drugs tested against Legionella species. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 11(8), 751-5. https://doi.org/10.1007/BF01989985
Johnson, D M, et al. "Antimicrobial activity of ten macrolide, lincosamine and streptogramin drugs tested against Legionella species." European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology vol. 11,8 (1992): 751-5. doi: https://doi.org/10.1007/BF01989985
Johnson DM, Erwin ME, Barrett MS, Gooding BB, Jones RN. Antimicrobial activity of ten macrolide, lincosamine and streptogramin drugs tested against Legionella species. Eur J Clin Microbiol Infect Dis. 1992 Aug;11(8):751-5. doi: 10.1007/BF01989985. PMID: 1425738.
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Eur J Clin Microbiol Infect Dis. 1992 Aug;11(8):751-5. doi: 10.1007/BF01989985.

Antimicrobial activity of ten macrolide, lincosamine and streptogramin drugs tested against Legionella species.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

D M Johnson, M E Erwin, M S Barrett, B B Gooding, R N Jones

Affiliations

  1. Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.

PMID: 1425738 DOI: 10.1007/BF01989985

Abstract

RP59500, a semisynthetic pristinamycin combination, and 14 other antimicrobial agents were tested against 108 Legionella strains. Of the ten macrolide, lincosamine and streptogramin agents tested, the new streptogramin RP59500 ranked seventh in order of activity against Legionella pneumophila on the basis of MIC90 results as follows: clarithromycin = 14-OH clarithromycin (MIC90 0.12 mg/l) > roxithromycin > erythromycin = tylosin = virginiamycin > RP59500 (MIC90 1 mg/l) = azithromycin > dirithromycin > clindamycin (MIC90 8 mg/l). Of all 14 drugs tested in this study, rifampicin was the most potent with an MIC90 of 0.008 mg/l. In this retrospective study of Legionella strains (1981-1990 isolates), we observed no trend toward resistance to the agents investigated.

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