Display options
Cite
Arvieux CC, Pernin C, Drouet N, et al. Comparative effects of halothane associated with verapamil and ischaemia on myocardial metabolism in isolated perfused rat hearts. Eur J Anaesthesiol. 1992;9(6):447-55
Arvieux, C. C., Pernin, C., Drouet, N., Mathieu, J. P., Hamant, S., Dubois, F., Cuchet, P., Stieglitz, P., & Comet, M. (1992). Comparative effects of halothane associated with verapamil and ischaemia on myocardial metabolism in isolated perfused rat hearts. European journal of anaesthesiology, 9(6), 447-55.
Arvieux, C C, et al. "Comparative effects of halothane associated with verapamil and ischaemia on myocardial metabolism in isolated perfused rat hearts." European journal of anaesthesiology vol. 9,6 (1992): 447-55.
Arvieux CC, Pernin C, Drouet N, Mathieu JP, Hamant S, Dubois F, Cuchet P, Stieglitz P, Comet M. Comparative effects of halothane associated with verapamil and ischaemia on myocardial metabolism in isolated perfused rat hearts. Eur J Anaesthesiol. 1992 Nov;9(6):447-55. PMID: 1425613.
Copy Download .nbib Format: NLM
Share it on

Eur J Anaesthesiol. 1992 Nov;9(6):447-55.

Comparative effects of halothane associated with verapamil and ischaemia on myocardial metabolism in isolated perfused rat hearts.

European journal of anaesthesiology

C C Arvieux, C Pernin, N Drouet, J P Mathieu, S Hamant, F Dubois, P Cuchet, P Stieglitz, M Comet

Affiliations

  1. Département d'Anesthésie Réanimation, Université J. Fourier, C.H.U de Grenoble, France.

PMID: 1425613

Abstract

The association of verapamil with halothane causes ischaemic-like myocardial dysfunction. Using an isolated rat heart model perfused with a radiolabelled fatty acid (123I-labelled iodohexadecenoic acid) as a sensitive marker of ischaemia this study investigated whether or not this dysfunction is of ischaemic origin. Hearts were perfused with a control solution or with solutions containing either 1% of halothane or 150 ng ml-1 of verapamil or the association of 0.75% halothane + 120 ng ml-1 verapamil. The ischaemic group was perfused at a reduced perfusion rate (-50%). Intracellular fate of IHA was assessed, and its esterification ratio computed. Ischaemia and the drugs induced a similar depression of haemodynamics. The esterification ratio in the ischaemic group was significantly higher (0.723 +/- 0.04) than in controls (0.0526 +/- 0.03) and than in the treated groups: halothane (0.533 +/- 0.06), verapamil (0.411 +/- 0.027) or the association halothane+verapamil (0.408 +/- 0.05), suggesting a non-ischaemic origin for the dysfunction caused by halothane-verapamil.

Substances

MeSH terms

Publication Types