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Thomson AH, Coote J, MacPherson L, et al. Bayesian estimation of streptomycin pharmacokinetics. Ther Drug Monit. 1992;14(6):522-4doi: 10.1097/00007691-199212000-00014.
Thomson, A. H., Coote, J., MacPherson, L., & Gordon, J. (1992). Bayesian estimation of streptomycin pharmacokinetics. Therapeutic drug monitoring, 14(6), 522-4. https://doi.org/10.1097/00007691-199212000-00014
Thomson, A H, et al. "Bayesian estimation of streptomycin pharmacokinetics." Therapeutic drug monitoring vol. 14,6 (1992): 522-4. doi: https://doi.org/10.1097/00007691-199212000-00014
Thomson AH, Coote J, MacPherson L, Gordon J. Bayesian estimation of streptomycin pharmacokinetics. Ther Drug Monit. 1992 Dec;14(6):522-4. doi: 10.1097/00007691-199212000-00014. PMID: 1485376.
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Ther Drug Monit. 1992 Dec;14(6):522-4. doi: 10.1097/00007691-199212000-00014.

Bayesian estimation of streptomycin pharmacokinetics.

Therapeutic drug monitoring

A H Thomson, J Coote, L MacPherson, J Gordon

Affiliations

  1. Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland.

PMID: 1485376 DOI: 10.1097/00007691-199212000-00014

Abstract

Streptomycin dose requirements were determined in an 83-year-old man with renal impairment who was being treated for miliary tuberculosis. Concentration measurements were interpreted using a Bayesian parameter estimation program. Estimated creatinine clearance (1.1 L/h) was used as a starting value for streptomycin clearance, and volume was initially assumed to be 0.3 L/kg. Bayesian estimates of clearance were close to the starting value and declined from 1.4 L/h to 0.9 L/h during the course of therapy. Volume was higher than the initial estimate (0.4-0.5 L/kg), possibly due to the patient having a low albumin and being underweight. Satisfactory concentrations were maintained for several weeks with doses of 500 mg every 36-48 h.

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