Display options
Cite
Neiger RD, Osweiler GD. Arsenic concentrations in tissues and body fluids of dogs on chronic low-level dietary sodium arsenite. J Vet Diagn Invest. 1992;4(3):334-7doi: 10.1177/104063879200400318.
Neiger, R. D., & Osweiler, G. D. (1992). Arsenic concentrations in tissues and body fluids of dogs on chronic low-level dietary sodium arsenite. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 4(3), 334-7. https://doi.org/10.1177/104063879200400318
Neiger, R D, and Osweiler, G D. "Arsenic concentrations in tissues and body fluids of dogs on chronic low-level dietary sodium arsenite." Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc vol. 4,3 (1992): 334-7. doi: https://doi.org/10.1177/104063879200400318
Neiger RD, Osweiler GD. Arsenic concentrations in tissues and body fluids of dogs on chronic low-level dietary sodium arsenite. J Vet Diagn Invest. 1992 Jul;4(3):334-7. doi: 10.1177/104063879200400318. PMID: 1515496.
Copy Download .nbib Format: NLM
Share it on
Full text links
Atypon

J Vet Diagn Invest. 1992 Jul;4(3):334-7. doi: 10.1177/104063879200400318.

Arsenic concentrations in tissues and body fluids of dogs on chronic low-level dietary sodium arsenite.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

R D Neiger, G D Osweiler

Affiliations

  1. Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Iowa State University, Ames 50011.

PMID: 1515496 DOI: 10.1177/104063879200400318

Abstract

Twenty-four female Beagle dogs, 7-8 months old, were assigned to 4 groups. Control, low-dosage, medium-dosage, and high-dosage groups were offered 0, 1, 2, and 4 mg of sodium arsenite per kilogram of body weight per day (mg/kg/day), respectively, in their feed (equivalent to 0.0, 33.4, 66.7, and 133.4 micrograms/g in feed). On day 59, the dosage was doubled for the rest of the experiment, which ended on day 183. In general, arsenic concentrations in tissues and body fluids reflected arsenic levels in feed. Arsenic caused a dose-related decrease in food intake. Statistically significant differences in blood, liver, and kidney arsenic were detected, in most cases, between the 2 higher dosage groups and controls. The greatest differences in arsenic concentrations between groups were present in urine and hair. Results indicate that urine and hair would be the most useful specimens for chemical analysis when attempting to confirm low-level dietary inorganic arsenic exposure or poisoning.

Similar articles

Cited by

Substances

MeSH terms

Publication Types

LinkOut - more resources