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Chiu KW, Lee YC. Cardiac activity of some peptide hormones in the frog, Rana tigrina. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992;103(3):483-7doi: 10.1016/0742-8413(92)90169-8.
Chiu, K. W., & Lee, Y. C. (1992). Cardiac activity of some peptide hormones in the frog, Rana tigrina. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 103(3), 483-7. https://doi.org/10.1016/0742-8413(92)90169-8
Chiu, K W, and Lee, Y C. "Cardiac activity of some peptide hormones in the frog, Rana tigrina." Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology vol. 103,3 (1992): 483-7. doi: https://doi.org/10.1016/0742-8413(92)90169-8
Chiu KW, Lee YC. Cardiac activity of some peptide hormones in the frog, Rana tigrina. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Nov;103(3):483-7. doi: 10.1016/0742-8413(92)90169-8. PMID: 1363298.
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Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Nov;103(3):483-7. doi: 10.1016/0742-8413(92)90169-8.

Cardiac activity of some peptide hormones in the frog, Rana tigrina.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

K W Chiu, Y C Lee

Affiliations

  1. Department of Biology, Chinese University of Hong Kong.

PMID: 1363298 DOI: 10.1016/0742-8413(92)90169-8

Abstract

1. The cardiac responses of isolated frog (Rana tigrina) atria to peptide hormones were studied. 2. Calcitonin gene-related peptide (CGRP), arginine vasotocin (AVT), bovine parathyroid hormone fragment (bPTH-(1-34)) and oxytocin (OXY) produced dose-related positive chronotropic and inotropic responses; atrial natriuretic peptide (ANP) was negative chronotropic and inotropic; cholecystokinin (CCK), vasoactive intestinal peptide (VIP) were without effects. 3. The dose-related responses under bPTH-(1-34) stimulation but not CGRP or AVT were attenuated in the presence of ANP (300 ng/ml, approximately 0.98 x 10(-7) M). As expected ANP decreased the basal AR and AT responses of the isolated atria and the inhibitory effects were dose-dependent. 4. As shown previously, propranolol blocked the atrial tension stimulated by bPTH (1-34) but did not alter the cardiac responses to CGRP and AVT. 5. In the presence of beta-adrenergic blocker (propranolol 10(-7) M) or ANP (10(-7) M), the AR and AT changes under ISO stimulation in the frog were also decreased. 6. These cardiac changes suggest the cardiac inhibitory effects of ANP are related to beta-adrenoceptor activity and ANP might be a beta antagonist.

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