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Clemente C, Russo F, Caruso MG, et al. Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times. Horm Metab Res. 1992;24(4):191-3doi: 10.1055/s-2007-1003291.
Clemente, C., Russo, F., Caruso, M. G., Giangrande, M., Fanizza, G., & Di Leo, A. (1992). Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 24(4), 191-3. https://doi.org/10.1055/s-2007-1003291
Clemente, C, et al. "Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme vol. 24,4 (1992): 191-3. doi: https://doi.org/10.1055/s-2007-1003291
Clemente C, Russo F, Caruso MG, Giangrande M, Fanizza G, Di Leo A. Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times. Horm Metab Res. 1992 Apr;24(4):191-3. doi: 10.1055/s-2007-1003291. PMID: 1318259.
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Georg Thieme Verlag Stuttgart, New York

Horm Metab Res. 1992 Apr;24(4):191-3. doi: 10.1055/s-2007-1003291.

Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

C Clemente, F Russo, M G Caruso, M Giangrande, G Fanizza, A Di Leo

Affiliations

  1. Laboratorio di Biochimica, I.R.C.C.S.S. de Bellis Castellana G., Bari, Italy.

PMID: 1318259 DOI: 10.1055/s-2007-1003291

Abstract

The liver is an estrogen-responsive organ and the administration of estrogens in humans increases the hepatic synthesis of many proteins. The existence of a circadian rhythm of estrogen receptors in the liver has been proved by different authors. We studied the presence of a different responsiveness of the human liver to the estrogens in two groups of post-menopausal women by evaluating the changes in ceruloplasmin serum level. Conjugated equine estrogens were administered at different times (A: 8 a.m. and B: 8 p.m.). The replacement therapy increased ceruloplasmin serum levels both in group A and B, but the increase was higher in group B than in group A. These data reflect indirectly the presence of a circadian rhythm of hepatic responsiveness to the estrogens.

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