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Fallo F, D'Agostino D, Armanini D, et al. Concomitant release of renin, angiotensin I, and angiotensin II during superfusion of human juxtaglomerular cell tumor. Am J Hypertens. 1992;5(8):566-9doi: 10.1093/ajh/5.8.566.
Fallo, F., D'Agostino, D., Armanini, D., Caregaro, L., & Mantero, F. (1992). Concomitant release of renin, angiotensin I, and angiotensin II during superfusion of human juxtaglomerular cell tumor. American journal of hypertension, 5(8), 566-9. https://doi.org/10.1093/ajh/5.8.566
Fallo, F, et al. "Concomitant release of renin, angiotensin I, and angiotensin II during superfusion of human juxtaglomerular cell tumor." American journal of hypertension vol. 5,8 (1992): 566-9. doi: https://doi.org/10.1093/ajh/5.8.566
Fallo F, D'Agostino D, Armanini D, Caregaro L, Mantero F. Concomitant release of renin, angiotensin I, and angiotensin II during superfusion of human juxtaglomerular cell tumor. Am J Hypertens. 1992 Aug;5(8):566-9. doi: 10.1093/ajh/5.8.566. PMID: 1388967.
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Am J Hypertens. 1992 Aug;5(8):566-9. doi: 10.1093/ajh/5.8.566.

Concomitant release of renin, angiotensin I, and angiotensin II during superfusion of human juxtaglomerular cell tumor.

American journal of hypertension

F Fallo, D D'Agostino, D Armanini, L Caregaro, F Mantero

Affiliations

  1. Institute of Semeiotica Medica, University of Padova, Italy.

PMID: 1388967 DOI: 10.1093/ajh/5.8.566

Abstract

Increasing evidence indicates that angiotensin II can be formed by juxtaglomerular cells (JGC) and cosecreted with renin. We investigated the existence of this local renin-angiotensin system in a human JGC tumor, using an in vitro superfusion. The JGC tumor was found concomitantly to release renin and angiotensin I and II. Sequential addition of atrial natriuretic peptide, dopamine, and a somatostatin analog in the superfusion did not affect renin or angiotensin I and II release. The data provide evidence that the human JGC tumor in vitro generates angiotensin II, and supports its possible role as a local in vivo regulator of kidney function.

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