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Oppenheimer SM, Gelb A, Girvin JP, et al. Cardiovascular effects of human insular cortex stimulation. Neurology. 1992;42(9):1727-32doi: 10.1212/wnl.42.9.1727.
Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C. (1992). Cardiovascular effects of human insular cortex stimulation. Neurology, 42(9), 1727-32. https://doi.org/10.1212/wnl.42.9.1727
Oppenheimer, S M, et al. "Cardiovascular effects of human insular cortex stimulation." Neurology vol. 42,9 (1992): 1727-32. doi: https://doi.org/10.1212/wnl.42.9.1727
Oppenheimer SM, Gelb A, Girvin JP, Hachinski VC. Cardiovascular effects of human insular cortex stimulation. Neurology. 1992 Sep;42(9):1727-32. doi: 10.1212/wnl.42.9.1727. PMID: 1513461.
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Neurology. 1992 Sep;42(9):1727-32. doi: 10.1212/wnl.42.9.1727.

Cardiovascular effects of human insular cortex stimulation.

Neurology

S M Oppenheimer, A Gelb, J P Girvin, V C Hachinski

Affiliations

  1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

PMID: 1513461 DOI: 10.1212/wnl.42.9.1727

Abstract

Recent investigations indicate a site of cardiac representation within the left insular cortex of the rat. Moreover, the results of lesion studies suggest left-sided insular dominance for sympathetic cardiovascular effects. It is unclear whether similar representation exists within the human insular cortex. Five epileptic patients underwent intraoperative insular stimulation prior to temporal lobectomy for seizure control. On stimulation of the left insular cortex, bradycardia and depressor responses were more frequently produced than tachycardia and pressor effects (p less than 0.005). The converse applied for the right insular cortex. We believe this to be the first demonstration of cardiovascular changes elicitable during insular stimulation in humans, and of lateralization of such responses for a cortical site. In humans, unlike the rat, there appears to be right-sided dominance for sympathetic effects. These findings may be of relevance in predicting the autonomic effects of stroke in humans and in the explanation of sudden unexpected epileptic death.

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