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Clerici M, Landay AL, Kessler HA, et al. Reconstitution of long-term T helper cell function after zidovudine therapy in human immunodeficiency virus-infected patients. J Infect Dis. 1992;166(4):723-30doi: 10.1093/infdis/166.4.723.
Clerici, M., Landay, A. L., Kessler, H. A., Phair, J. P., Venzon, D. J., Hendrix, C. W., Lucey, D. R., & Shearer, G. M. (1992). Reconstitution of long-term T helper cell function after zidovudine therapy in human immunodeficiency virus-infected patients. The Journal of infectious diseases, 166(4), 723-30. https://doi.org/10.1093/infdis/166.4.723
Clerici, M, et al. "Reconstitution of long-term T helper cell function after zidovudine therapy in human immunodeficiency virus-infected patients." The Journal of infectious diseases vol. 166,4 (1992): 723-30. doi: https://doi.org/10.1093/infdis/166.4.723
Clerici M, Landay AL, Kessler HA, Phair JP, Venzon DJ, Hendrix CW, Lucey DR, Shearer GM. Reconstitution of long-term T helper cell function after zidovudine therapy in human immunodeficiency virus-infected patients. J Infect Dis. 1992 Oct;166(4):723-30. doi: 10.1093/infdis/166.4.723. PMID: 1388195.
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J Infect Dis. 1992 Oct;166(4):723-30. doi: 10.1093/infdis/166.4.723.

Reconstitution of long-term T helper cell function after zidovudine therapy in human immunodeficiency virus-infected patients.

The Journal of infectious diseases

M Clerici, A L Landay, H A Kessler, J P Phair, D J Venzon, C W Hendrix, D R Lucey, G M Shearer

Affiliations

  1. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

PMID: 1388195 DOI: 10.1093/infdis/166.4.723

Abstract

Peripheral blood mononuclear cells from 12 asymptomatic patients infected with immunodeficiency virus (HIV) and 4 patients with AIDS were analyzed before and during therapy with zidovudine for T helper cell (Th) function. Th function improved by more than fourfold to one or more of three stimuli tested in 9 (75%) of 12 asymptomatic patients on zidovudine therapy and in 3 of 4 patients with AIDS. Only 6 (7.4%) of 80 untreated HIV-infected control patients showed spontaneous improvement in Th function (P less than 10(-6)). Improved Th function was detected as early as 5 weeks into therapy in 6 patients and continued to be evident for greater than 1 year after start of therapy in 6 patients and for greater than 2 years in 2 patients. No correlation was observed between improved Th function and changes in CD4+ or CD8+ cell numbers or in levels of serum HIV p24 antigen or beta 2-microglobulin. These results suggest inclusion of in vitro Th function as a useful marker in determining the efficacy of antiretroviral drug therapy of HIV-infected patients.

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