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Hamilton CA. The role of imidazoline receptors in blood pressure regulation. Pharmacol Ther. 1992;54(3):231-48doi: 10.1016/0163-7258(92)90001-g.
Hamilton, C. A. (1992). The role of imidazoline receptors in blood pressure regulation. Pharmacology & therapeutics, 54(3), 231-48. https://doi.org/10.1016/0163-7258(92)90001-g
Hamilton, C A. "The role of imidazoline receptors in blood pressure regulation." Pharmacology & therapeutics vol. 54,3 (1992): 231-48. doi: https://doi.org/10.1016/0163-7258(92)90001-g
Hamilton CA. The role of imidazoline receptors in blood pressure regulation. Pharmacol Ther. 1992;54(3):231-48. doi: 10.1016/0163-7258(92)90001-g. PMID: 1361236.
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Elsevier Science

Pharmacol Ther. 1992;54(3):231-48. doi: 10.1016/0163-7258(92)90001-g.

The role of imidazoline receptors in blood pressure regulation.

Pharmacology & therapeutics

C A Hamilton

Affiliations

  1. Department of Medicine and Therapeutics, Western Infirmary, Glasgow, U.K.

PMID: 1361236 DOI: 10.1016/0163-7258(92)90001-g

Abstract

Using the ligands [3H] clonidine and [3H] idazoxan, nonadrenergic imidazoline preferring binding sites have been identified in a range of tissues from several species including man. These sites may represent a new family of receptors. An endogenous ligand and potential clonidine displacing substance has been identified. There is strong evidence for an involvement of the nonadrenergic imidazoline [3H] clonidine labelled sites in the nucleus reticularis lateralis in blood pressure regulation, and some evidence for a role in sodium regulation in the kidney for the [3H] idazoxan labelled sites. Some drugs which were previously thought to act via alpha 2-adrenoceptors, may mediate their effects in part via these imidazoline sites.

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