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Rappolee DA, Sturm KS, Behrendtsen O, et al. Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. Genes Dev. 1992;6(6):939-52doi: 10.1101/gad.6.6.939.
Rappolee, D. A., Sturm, K. S., Behrendtsen, O., Schultz, G. A., Pedersen, R. A., & Werb, Z. (1992). Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. Genes & development, 6(6), 939-52. https://doi.org/10.1101/gad.6.6.939
Rappolee, D A, et al. "Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos." Genes & development vol. 6,6 (1992): 939-52. doi: https://doi.org/10.1101/gad.6.6.939
Rappolee DA, Sturm KS, Behrendtsen O, Schultz GA, Pedersen RA, Werb Z. Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. Genes Dev. 1992 Jun;6(6):939-52. doi: 10.1101/gad.6.6.939. PMID: 1317321.
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Genes Dev. 1992 Jun;6(6):939-52. doi: 10.1101/gad.6.6.939.

Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.

Genes & development

D A Rappolee, K S Sturm, O Behrendtsen, G A Schultz, R A Pedersen, Z Werb

Affiliations

  1. Department of Anatomy, University of California, San Francisco 94143-0750.

PMID: 1317321 DOI: 10.1101/gad.6.6.939
Free Article

Abstract

We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages. mRNA and protein for IGF-II were expressed in preimplantation mouse embryos, but the related factors IGF-I and insulin were not. IGF-I and insulin receptors and the IGF-II/mannose-6-phosphate receptor were expressed. Exogenous IGF-II or IGF-I increased the cell number in cultured blastocysts, but a mutant form of IGF-II that strongly binds only the IGF-II receptor did not. Reduction of IGF-II expression by antisense IGF-II oligonucleotides decreased the rate of progression to the blastocyst stage and decreased the cell number in blastocysts. Preimplantation parthenogenetic mouse embryos expressed mRNA for the IGF-II receptor but not for either IGF-II ligand or the IGF-I receptor, indicating that the latter genes are not expressed when inherited maternally. These data imply that some growth factors and receptors, regulated by genomic imprinting, may control cell proliferation from the earliest stages of embryonic development.

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