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Bowen AJ. Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs. J Int Med Res. 1978;6(4):337-42doi: 10.1177/030006057800600412.
Bowen, A. J. (1978). Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs. The Journal of international medical research, 6(4), 337-42. https://doi.org/10.1177/030006057800600412
Bowen, A J. "Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs." The Journal of international medical research vol. 6,4 (1978): 337-42. doi: https://doi.org/10.1177/030006057800600412
Bowen AJ. Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs. J Int Med Res. 1978;6(4):337-42. doi: 10.1177/030006057800600412. PMID: 28989.
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J Int Med Res. 1978;6(4):337-42. doi: 10.1177/030006057800600412.

Comparative efficacy of triazolam, flurazepam and placebo in out-patients insomniacs.

The Journal of international medical research

A J Bowen

PMID: 28989 DOI: 10.1177/030006057800600412
Free Article

Abstract

The short-term hypnotic efficacy of triazolam was compared to that of flurazepam and placebo in 120 out-patient insomniacs. Each patient was studied with a two-night, double-blind crossover trial. Triazolam (0.5 mg) was compared to placebo and flurazepam (30 mg). Triazolam (0.25 mg) was compared to flurazepam (15 mg and 30 mg). Triazolam (0.5 mg) was preferred to both placebo and flurazepam (30 mg). Triazolam (0.5 mg) was superior to placebo in improving quality of sleep, shortening sleep onset, increasing sleep duration, and reducing the number of night-time awakenings. Triazolam (0.5 mg) was superior to flurazepam (30 mg) in speeding sleep onset and increasing the quality of sleep. Triazolam (0.25 mg) was preferred to flurazepam (15 mg) and was significantly better than flurazepam on all sleep questions. Triazolam (0.25 mg) was preferred by more patients than flurazepam (30 mg) and was judged equally efficacious on individual sleep questions. Reports of side-effects were minimal for both drugs.

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