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Pediatr Nephrol. 1992 Nov;6(6):547-9. doi: 10.1007/BF00866499.

Acute tubulointerstitial nephritis with uveitis syndrome presenting as multiple tubular dysfunction including Fanconi's syndrome.

Pediatric nephrology (Berlin, Germany)

T Igarashi, H Kawato, S Kamoshita, K Nosaka, K Seiya, H Hayakawa


  1. Department of Paediatrics, Faculty of Medicine, University of Tokyo, Japan.

PMID: 1482643 DOI: 10.1007/BF00866499


We describe an 11-year-old male patient with acute tubulointerstitial nephritis with uveitis (TINU) syndrome. He presented with easy fatigability, pallor, nocturia and weight loss. Laboratory examination disclosed anaemia, polyclonal hypergammaglobulinaemia, low molecular weight proteinuria, glycosuria, aminoaciduria, proximal and distal renal tubular acidosis, a urine concentration defect and decreased creatinine clearance. The multiple renal tubular dysfunction and slight glomerular dysfunction subsided spontaneously. Bilateral anterior uveitis was manifested 7 months after the onset of the disease. This is the first reported case of TINU syndrome with multiple proximal and distal tubular dysfunction including a complete type of Fanconi's syndrome.

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