Zhongguo Yao Li Xue Bao. 1992 Jul;13(4):289-92.

Effects of l-stepholidine on tyrosine hydroxylase activity in rat corpus striatum.

Zhongguo yao li xue bao = Acta pharmacologica Sinica

X Guo, L J Chen, M Buda, G Z Jin

PMID: 1360740

Abstract

l-Stepholidine (SPD) 2.5 and haloperidol (Hal) 1.0 mg.kg-1 ip increased rat striatal L-3,4-dihydroxyphenylalanine (DOPA) and 3,4-dihydroxyphenylacetic acid (DOPAC) accumulation induced by NSD 1015 (50 mg.kg-1, ip), a decarboxylase inhibitor. SPD (2.5 mg.kg-1, ip) did not alter but apomorphine (2.0 mg.kg-1, ip) decreased the dopamine (DA) content elevated by gamma-butyrolactone (GBL, 750 mg.kg-1, ip) in the rat striatum. Ip injection of either SPD 5.0 or Hal 2.5 mg.kg-1 after NSD 1015 50 mg.kg-1 or NSD 1015 plus GBL 750 mg.kg-1 also augmented tyrosine hydroxylase (TH) activity in the rat striatum. These results suggest that SPD produces an antagonistic effect on presynaptic DA receptors.

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Substances

• Berberine
• stepholidine
• 3,4-Dihydroxyphenylacetic Acid
• Dihydroxyphenylalanine
• Tyrosine 3-Monooxygenase
• Haloperidol
• Apomorphine
• Dopamine

MeSH terms

• 3,4-Dihydroxyphenylacetic Acid / metabolism
• Animals
• Apomorphine / pharmacology
• Berberine / analogs & derivatives
• Berberine / pharmacology
• Corpus Striatum / enzymology
• Dihydroxyphenylalanine / metabolism
• Dopamine / metabolism
• Haloperidol / pharmacology
• Male
• Rats
• Rats, Sprague-Dawley
• Stereoisomerism
• Tyrosine 3-Monooxygenase / metabolism

Publication Types

• Journal Article

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