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Hirschberg R, Kopple JD. The growth hormone-insulin-like growth factor I axis and renal glomerular function. J Am Soc Nephrol. 1992;2(9):1417-22doi: 10.1681/ASN.V291417.
Hirschberg, R., & Kopple, J. D. (1992). The growth hormone-insulin-like growth factor I axis and renal glomerular function. Journal of the American Society of Nephrology : JASN, 2(9), 1417-22. https://doi.org/10.1681/ASN.V291417
Hirschberg, R, and Kopple, J D. "The growth hormone-insulin-like growth factor I axis and renal glomerular function." Journal of the American Society of Nephrology : JASN vol. 2,9 (1992): 1417-22. doi: https://doi.org/10.1681/ASN.V291417
Hirschberg R, Kopple JD. The growth hormone-insulin-like growth factor I axis and renal glomerular function. J Am Soc Nephrol. 1992 Mar;2(9):1417-22. doi: 10.1681/ASN.V291417. PMID: 1385734.
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J Am Soc Nephrol. 1992 Mar;2(9):1417-22. doi: 10.1681/ASN.V291417.

The growth hormone-insulin-like growth factor I axis and renal glomerular function.

Journal of the American Society of Nephrology : JASN

R Hirschberg, J D Kopple

Affiliations

  1. Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance.

PMID: 1385734 DOI: 10.1681/ASN.V291417
Free Article

Abstract

This study examined whether maneuvers that chronically raise or lower serum insulin-like growth factor I (IGF-I), within physiological and pathophysiological ranges, will affect glomerular hemodynamics. Pair-fed Munich Wistar rats received, for 6 to 7 days, continuous s.c. infusions of human recombinant IGF-I (rhIGF-I; 125 micrograms/day), vehicle, or s.c. injection of a synthetic growth hormone-releasing hormone antagonist (GHRH-ANT) (N = 7 in each group). Infusion of rhIGF-I raised serum IGF-I to about 180% of control values, and GHRH-ANT injections lowered serum IGF-I to about 33% of control. The IGF-I infusion induced an increase in left kidney weight when expressed in absolute units but not when expressed as a percentage of body weight; there was also an increase in glomerular volume in the IGF-I treated rats. GFR, single nephron GFR, and single nephron plasma flow also rose with IGF-I infusion, and these changes were associated with decreased afferent and efferent arteriolar resistance and increased glomerular ultrafiltration coefficient. GHRH-ANT injection did not affect kidney weight or glomerular volume; however, GFR, single nephron GFR, and single nephron plasma flow were reduced in association with an increase in efferent arteriolar resistance. There also was a tendency, not significant, for the glomerular ultrafiltration coefficient to decrease. The findings that a low dose of rhIGF-I, which raised the serum IGF-I only modestly, increased glomerular ultrafiltration and that reducing serum IGF-I below control values decreased glomerular dynamics suggest that physiological or pathophysiological changes in IGF-I may affect and possible help to regulate glomerular function.(ABSTRACT TRUNCATED AT 250 WORDS)

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