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Krentz AJ, Clark PM, Cox L, et al. Hyperproinsulinaemia in patients with myotonic dystrophy. Diabetologia. 1992;35(12):1170-2doi: 10.1007/BF00401372.
Krentz, A. J., Clark, P. M., Cox, L., Williams, A. C., & Nattrass, M. (1992). Hyperproinsulinaemia in patients with myotonic dystrophy. Diabetologia, 35(12), 1170-2. https://doi.org/10.1007/BF00401372
Krentz, A J, et al. "Hyperproinsulinaemia in patients with myotonic dystrophy." Diabetologia vol. 35,12 (1992): 1170-2. doi: https://doi.org/10.1007/BF00401372
Krentz AJ, Clark PM, Cox L, Williams AC, Nattrass M. Hyperproinsulinaemia in patients with myotonic dystrophy. Diabetologia. 1992 Dec;35(12):1170-2. doi: 10.1007/BF00401372. PMID: 1478370.
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Diabetologia. 1992 Dec;35(12):1170-2. doi: 10.1007/BF00401372.

Hyperproinsulinaemia in patients with myotonic dystrophy.

Diabetologia

A J Krentz, P M Clark, L Cox, A C Williams, M Nattrass

Affiliations

  1. Diabetic Clinic, General Hospital, Birmingham, UK.

PMID: 1478370 DOI: 10.1007/BF00401372

Abstract

Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after an overnight fast in ten patients with myotonic dystrophy using two-site monoclonal antibody-based immunoradiometric assays. Results were compared with ten healthy control subjects matched for age, gender, and body mass index. Oral glucose tolerance (75 g), as defined by World Health Organization criteria, was normal in all subjects. Fasting plasma immunoreactive insulin concentration, as determined using a conventional radioimmunoassay, was almost three times higher (p < 0.005) in the myotonic dystrophy patients than the healthy control subjects. By contrast, fasting concentrations (mean +/- SEM) of C-peptide (0.75 +/- 0.09 vs 0.52 +/- 0.03 nmol/l, p = 0.07) and immunoradiometrically-determined insulin (60 +/- 12 vs 38 +/- 4 pmol/l, p = 0.09) were not significantly different between the groups. Fasting concentrations of proinsulin (10.3 +/- 2.9 vs 1.6 +/- 0.3 pmol/l, p < 0.01), and 32-33 split proinsulin (7.8 +/- 2.5 vs 2.9 +/- 0.4 pmol/l, p < 0.05) were significantly elevated in the patients with myotonic dystrophy. Accordingly, the mean fasting proinsulin:insulin ratio, expressed as a percentage, was significantly increased in the myotonic patients (20 +/- 5 vs 4 +/- 1%, p < 0.01). The overall C-peptide response to the oral glucose challenge was significantly greater in the myotonic patients compared with the healthy control subjects (p < 0.001). These results provide corroborative evidence of increased beta-cell secretion in myotonic dystrophy.(ABSTRACT TRUNCATED AT 250 WORDS)

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