Scand J Immunol Suppl. 1992;11:187-91. doi: 10.1111/j.1365-3083.1992.tb01649.x.

Identification of genetic susceptibility loci for insulin-dependent diabetes in Sudan.

Scandinavian journal of immunology. Supplement

M M Magzoub, H A Stephens, E A Gale, G Franco Bottazzo

PMID: 1355306 DOI: 10.1111/j.1365-3083.1992.tb01649.x

Abstract

In this study we report, for the first time, the molecular analysis of HLA-DR and DQ gene frequencies in a large cohort of well-characterized type 1 (insulin-dependent) diabetes mellitus (IDDM) patients (n = 72), and ethnically matched controls (n = 59) collected in sub-Saharan Africa. High molecular mass DNA was prepared and analysed in Southern blots and by oligonucleotide typing. We have shown a strong positive association between IDDM and the Asp 57- DQB1 allele *0201 (DQw2). A rare DR4, DQw2 haplotype was also identified at high frequency in the IDDM cohort. We can now confirm that the association between Asp 57- DQB1 alleles and IDDM, previously reported in ethnically diverse cohorts collected in Western Europe, North America, and South Asia, is also present in an IDDM cohort collected in Africa.

Substances

• HLA-DQ Antigens
• HLA-DR Antigens

MeSH terms

• Adolescent
• Adult
• Alleles
• Base Sequence
• Child
• Chromosome Mapping*
• Diabetes Mellitus, Type 1 / genetics
• Diabetes Mellitus, Type 1 / immunology
• Gene Frequency
• Genetic Predisposition to Disease*
• HLA-DQ Antigens / genetics
• HLA-DR Antigens / genetics
• Humans
• Molecular Sequence Data
• Polymorphism, Restriction Fragment Length

Publication Types

• Journal Article

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