Display options
Cite
Marcovitz PM, Aisen AM, Fencil LE, et al. Metabolic effects of adenosine on regional myocardial ischemia by phosphorus 31 nuclear magnetic resonance spectroscopy. Am Heart J. 1992;124(5):1205-12doi: 10.1016/0002-8703(92)90401-g.
Marcovitz, P. M., Aisen, A. M., Fencil, L. E., Swanson, S. D., & Buda, A. J. (1992). Metabolic effects of adenosine on regional myocardial ischemia by phosphorus 31 nuclear magnetic resonance spectroscopy. American heart journal, 124(5), 1205-12. https://doi.org/10.1016/0002-8703(92)90401-g
Marcovitz, P M, et al. "Metabolic effects of adenosine on regional myocardial ischemia by phosphorus 31 nuclear magnetic resonance spectroscopy." American heart journal vol. 124,5 (1992): 1205-12. doi: https://doi.org/10.1016/0002-8703(92)90401-g
Marcovitz PM, Aisen AM, Fencil LE, Swanson SD, Buda AJ. Metabolic effects of adenosine on regional myocardial ischemia by phosphorus 31 nuclear magnetic resonance spectroscopy. Am Heart J. 1992 Nov;124(5):1205-12. doi: 10.1016/0002-8703(92)90401-g. PMID: 1442487.
Copy Download .nbib Format: NLM
Share it on
Full text links
Elsevier Science

Am Heart J. 1992 Nov;124(5):1205-12. doi: 10.1016/0002-8703(92)90401-g.

Metabolic effects of adenosine on regional myocardial ischemia by phosphorus 31 nuclear magnetic resonance spectroscopy.

American heart journal

P M Marcovitz, A M Aisen, L E Fencil, S D Swanson, A J Buda

Affiliations

  1. Department of Internal Medicine (Division of Cardiology), University of Michigan Medical Center, Ann Arbor.

PMID: 1442487 DOI: 10.1016/0002-8703(92)90401-g

Abstract

The metabolic effects of adenosine on regionally ischemic myocardium were investigated in an open-chest rabbit model by means of phosphorus 31 nuclear magnetic resonance (NMR) spectroscopy. Sixteen anesthetized New Zealand white rabbits were subjected to thoracotomy; a reversible snare occluder was placed around a large branch of the left circumflex coronary artery, and an NMR surface coil was positioned adjacent to the myocardium perfused by this vessel. The animals were placed in a 2.0 T CSI spectrometer (GE Medical Systems, Fremont, Calif.), and baseline spectra were acquired. Eight animals were treated with intravenous adenosine (25 mg/kg), and eight rabbits served as control subjects. All animals were subjected to a 10-minute period of ischemia followed by a period of reperfusion. NMR spectra were acquired during both intervals. During the occlusion period, expected increases in inorganic phosphate levels and decreases in phosphocreatine levels were observed in both groups; however, inorganic phosphate increased less in adenosine-treated animals (adenosine: 33 +/- 2.8% total spectral area during occlusion vs control: 41 +/- 3.1%) and phosphocreatine diminished less with adenosine (adenosine: 26 +/- 3% vs control: 13 +/- 1.2%; p < 0.002). No significant differences were seen in beta-adenosine triphosphate levels. In both groups the metabolite levels during reperfusion recovered to near baseline values, although phosphocreatine remained slightly higher in the treated group during early reperfusion. An apparent cardioprotective effect of adenosine on relative phosphocreatine and inorganic phosphate levels can be observed in intact rabbits by means of phosphorus 31 NMR spectroscopy.

Similar articles

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources