Oncogene. 1992 Sep;7(9):1879-84.

Lack of expression of tumor-suppressor genes in human malignant glioma cell lines.

Oncogene

R Godbout, J Miyakoshi, K D Dobler, R Andison, K Matsuo, M J Allalunis-Turner, H Takebe, R S Day

PMID: 1501894

Abstract

Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression. Yet, in the studies performed to date, the relationship between these alterations has not been addressed. In this report, we have studied gene expression in 29 malignant glioma cell lines and have determined that, although loss of the interferon genes and loss of RB, p53 and MGMT mRNAs are frequent events, combinations of genetic alterations involving these four proven or putative tumor-suppressor genes are relatively infrequent. The exception was loss of RB mRNA, which may be associated with lack of MGMT mRNA.

Substances

• Interferon-alpha
• RNA, Messenger
• Interferon-beta
• Methyltransferases
• O(6)-Methylguanine-DNA Methyltransferase

MeSH terms

• Chromosome Deletion
• Gene Expression*
• Genes, Retinoblastoma
• Genes, Tumor Suppressor*
• Glioma / genetics
• Humans
• Interferon-alpha / genetics
• Interferon-beta / genetics
• Methyltransferases / genetics
• O(6)-Methylguanine-DNA Methyltransferase
• RNA, Messenger / analysis
• Tumor Cells, Cultured

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't

LinkOut - more resources

• Medical
  • Genetic Alliance
• Miscellaneous
  • NCI CPTAC Assay Portal
• Research Materials
  • NCI CPTC Antibody Characterization Program