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Hsu JL, Visner GA, Burr IA, et al. Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison. Biochem Biophys Res Commun. 1992;186(2):936-43doi: 10.1016/0006-291x(92)90836-a.
Hsu, J. L., Visner, G. A., Burr, I. A., & Nick, H. S. (1992). Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison. Biochemical and biophysical research communications, 186(2), 936-43. https://doi.org/10.1016/0006-291x(92)90836-a
Hsu, J L, et al. "Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison." Biochemical and biophysical research communications vol. 186,2 (1992): 936-43. doi: https://doi.org/10.1016/0006-291x(92)90836-a
Hsu JL, Visner GA, Burr IA, Nick HS. Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison. Biochem Biophys Res Commun. 1992 Jul 31;186(2):936-43. doi: 10.1016/0006-291x(92)90836-a. PMID: 1379810.
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Elsevier Science

Biochem Biophys Res Commun. 1992 Jul 31;186(2):936-43. doi: 10.1016/0006-291x(92)90836-a.

Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison.

Biochemical and biophysical research communications

J L Hsu, G A Visner, I A Burr, H S Nick

Affiliations

  1. Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville 32610.

PMID: 1379810 DOI: 10.1016/0006-291x(92)90836-a

Abstract

A 13 kb rat Cu/ZnSOD genomic clone has been purified from a rat liver genomic library and completely characterized by restriction mapping, detailed sequencing and Southern blot analysis. This gene spans approximately 6 kb and contains five exons and four introns. Comparison of rat, mouse, and human Cu/ZnSOD genes reveals a high conservation in genomic organization and exon-intron junctions, including an unusual 5'GC donor sequence at the first intron. The gene contains a TATA box as well as an inverted CCAAT box, a feature common to both the mouse and human genes. Furthermore, several repeats were identified in the 5' promoter region of this gene, and these regulatory elements are also strikingly conserved in these three species.

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