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Neuroreport. 1992 Jan;3(1):7-9. doi: 10.1097/00001756-199201000-00001.

L-serine-O-phosphate blocks NMDA-evoked responses in the ampullae of Lorenzini of skates.

Neuroreport

G N Akoev, G N Andrianov, I V Ryzhova, N O Sherman

Affiliations

  1. Laboratory of Physiology of Reception, Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad.

PMID: 1351755 DOI: 10.1097/00001756-199201000-00001

Abstract

In the present study, we have shown by single afferent unit recording in the organs of Lorenzini that L-serine-O-phosphate (L-SOP) decreases the resting discharge frequency as well as electrically evoked responses. L-SOP in a concentration of 0.1-100 microM antagonizes responses induced by L-glutamate (L-GLU) and N-methyl-D-aspartate (NMDA) and has no effect on the responses to application of kainate (KA) and quisqualate (Q). The results obtained confirm previous observations about the existence of NMDA receptors in the afferent synapse of the ampullae of Lorenzini.

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