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Di Biase M, Chiddo A, Caruso G, et al. Ventricular premature beats in young subjects without evidence of cardiac disease: histological findings. Eur Heart J. 1992;13(6):732-7doi: 10.1093/oxfordjournals.eurheartj.a060248.
Di Biase, M., Chiddo, A., Caruso, G., Tritto, M., Marchese, A., & Rizzon, P. (1992). Ventricular premature beats in young subjects without evidence of cardiac disease: histological findings. European heart journal, 13(6), 732-7. https://doi.org/10.1093/oxfordjournals.eurheartj.a060248
Di Biase, M, et al. "Ventricular premature beats in young subjects without evidence of cardiac disease: histological findings." European heart journal vol. 13,6 (1992): 732-7. doi: https://doi.org/10.1093/oxfordjournals.eurheartj.a060248
Di Biase M, Chiddo A, Caruso G, Tritto M, Marchese A, Rizzon P. Ventricular premature beats in young subjects without evidence of cardiac disease: histological findings. Eur Heart J. 1992 Jun;13(6):732-7. doi: 10.1093/oxfordjournals.eurheartj.a060248. PMID: 1378010.
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Eur Heart J. 1992 Jun;13(6):732-7. doi: 10.1093/oxfordjournals.eurheartj.a060248.

Ventricular premature beats in young subjects without evidence of cardiac disease: histological findings.

European heart journal

M Di Biase, A Chiddo, G Caruso, M Tritto, A Marchese, P Rizzon

Affiliations

  1. Department of Cardiology, University of Bari, Italy.

PMID: 1378010 DOI: 10.1093/oxfordjournals.eurheartj.a060248

Abstract

This report describes the results of right ventricle endomyocardial biopsies from 26 subjects (mean age 27 +/- 10 years) with premature ventricular beats and normal cardiac anatomy and mechanical function. Light microscopy examination revealed normal myocardium in 10 subjects (38%), acute myocarditis in two (7%), borderline myocarditis in one (3.5%), non-specific histological abnormalities including cellular hypertrophy, fibrosis and degenerative changes in 11 (42%), vasculitis in one (3.5%) and findings compatible with right ventricular dysplasia in the final subject (3.5%). The frequency of ventricular premature beats, as assessed by Holter monitoring, and the results of electrophysiological testing did not correlate with histopathological findings and their severity. These data indicate that some young subjects with premature ventricular beats of unknown origin have abnormal right ventricular biopsy findings. Adequate follow-up will probably demonstrate the clinical utility of these observations.

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