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Reubi JC, Waser B, van Hagen M, et al. In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas. Int J Cancer. 1992;50(6):895-900doi: 10.1002/ijc.2910500613.
Reubi, J. C., Waser, B., van Hagen, M., Lamberts, S. W., Krenning, E. P., Gebbers, J. O., & Laissue, J. A. (1992). In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas. International journal of cancer, 50(6), 895-900. https://doi.org/10.1002/ijc.2910500613
Reubi, J C, et al. "In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas." International journal of cancer vol. 50,6 (1992): 895-900. doi: https://doi.org/10.1002/ijc.2910500613
Reubi JC, Waser B, van Hagen M, Lamberts SW, Krenning EP, Gebbers JO, Laissue JA. In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas. Int J Cancer. 1992 Apr 01;50(6):895-900. doi: 10.1002/ijc.2910500613. PMID: 1348240.
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Int J Cancer. 1992 Apr 01;50(6):895-900. doi: 10.1002/ijc.2910500613.

In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas.

International journal of cancer

J C Reubi, B Waser, M van Hagen, S W Lamberts, E P Krenning, J O Gebbers, J A Laissue

Affiliations

  1. Sandoz Research Institute, Berne, Switzerland.

PMID: 1348240 DOI: 10.1002/ijc.2910500613

Abstract

A wide variety of primary and metastatic human neoplasms express somatostatin receptors (SS-Rs). We evaluated the SS-R status of malignant lymphomas that had been surgically removed from 31 patients by use of in vitro SS-R autoradiography with the SS analog 125I-[Tyr3]-octreotide as radioligand. Of 11 low-grade-malignancy B-cell non-Hodgkin's lymphomas, 10 were SS-R-positive, with a high receptor density restricted to the neoplastic follicles. All of the 8 intermediate-grade lymphomas were SS-R-positive. Of the B-cell lymphomas of high-grade malignancy, 7 out of 10 were SS-R-positive, often with a high density of receptors. One T-cell lymphoma and one Hodgkin's lymphoma were also positive. SS-Rs were of high affinity (KD = 1.2 nM) and specific for bioactive SS analogs. In 4 patients, the lymphomas were localized in vivo by use of gamma-camera scintigraphy after i.v. injection of the SS analog 111In-[DTPA-D-Phe1]-octreotide. Hot spots, identified in all 4 patients, corresponded to SS-R-positive malignant-lymphoma tissue, as confirmed by receptor autoradiography of the surgically removed tumors. Our data show that SS-Rs are valuable pathobiochemical tissue markers and potentially useful in vivo diagnostic tools for human malignant lymphomas.

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PMID: 30034278

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