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Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003 Feb;17(2):68-70.

[The effect of proinflammatory cytokines in pathogenesis of chronic sinusitis].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology

[Article in Chinese]
Yanzhong Li, Zhensheng Fang, Zhihua Du, Wenbo Zhao

Affiliations

  1. State Otolaryngology Institute, P. R. China Shandong University, Jinan 250012.

PMID: 12833683

Abstract

OBJECTIVE: To investigate the effect of the proinflammatory cytokines, including IL-1, IL-8 and TNF in the pathogenesis of chronic sinusitis.

METHOD: Using immunohistochemical streptavidin-biotin peroxide complex (SABC) method to investigate the expression of interleukin-1 (IL-1), IL-8 and tumor necrosis factor (TNF) in the local mucosa of the two type chronic sinusitis.

RESULT: There were significantly large numbers of IL-1+, IL-8+ and TNF+ cell in chronic sinusitis type I compared with healthy control (P < 0.01). The numbers of IL-8+ and TNF+ cell in the chronic sinusitis type II were significantly larger than that in the healthy control (P < 0.01). The numbers of IL-1+ cell in chronic sinusitis type I were significantly larger than that in chronic sinusitis type II (P < 0.01).

CONCLUSION: This study indicates that proinflammatory cytokines may play an important role in the pathogenesis of chronic sinusitis. It appears that specific cytokine patterns are found in different forms of sinusitis. The investigation of different cytokine patterns may help to understand the different pathogenesis in chronic sinusitis subgroups.

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