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Rev Rhum Mal Osteoartic. 1992 Apr;59(4):258-63.

[Erythromelalgia in adults. Apropos of 16 cases].

Revue du rhumatisme et des maladies osteo-articulaires

[Article in French]
H Levesque, N Cailleux, H Courtois

Affiliations

  1. Service de Médecine Interne, Diabétologie, Angéiologie, CHU Rouen-Boisguillaume.

PMID: 1496272

Abstract

The authors report sixteen consecutive cases of erythromelalgia, an infrequent disease in which local heat, redness, and pain develop in the hands and/or feet in recurrent attacks. The disease was essential in nine patients; in the remaining seven, the cause was a myeloproliferative syndrome (polycythemia vera in 3 cases and thrombocythemia in 1 case) or a drug (bromocriptine, nicardipine, and nifedipine, one case each). Acetylsalicylic acid was effective in only six of the nine essential cases. Intravascular platelet activation and aggregation with plugging of the arterioles has been suggested as the mechanism of erythromelalgia in patients with myeloproliferative disorders. Other, as yet unelucidated pathophysiologic events underlie the juvenile-onset forms, which usually fail to respond to acetylsalicylic acid.

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