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Kasai M, Maziarz RT, Aoki K, et al. Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation. Mol Cell Biol. 1992;12(10):4751-7doi: 10.1128/mcb.12.10.4751-4757.1992.
Kasai, M., Maziarz, R. T., Aoki, K., Macintyre, E., & Strominger, J. L. (1992). Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation. Molecular and cellular biology, 12(10), 4751-7. https://doi.org/10.1128/mcb.12.10.4751-4757.1992
Kasai, M, et al. "Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation." Molecular and cellular biology vol. 12,10 (1992): 4751-7. doi: https://doi.org/10.1128/mcb.12.10.4751-4757.1992
Kasai M, Maziarz RT, Aoki K, Macintyre E, Strominger JL. Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation. Mol Cell Biol. 1992 Oct;12(10):4751-7. doi: 10.1128/mcb.12.10.4751-4757.1992. PMID: 1406658; PMCID: PMC360402.
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Atypon Free PMC Article

Mol Cell Biol. 1992 Oct;12(10):4751-7. doi: 10.1128/mcb.12.10.4751-4757.1992.

Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation.

Molecular and cellular biology

M Kasai, R T Maziarz, K Aoki, E Macintyre, J L Strominger

Affiliations

  1. Department of Immunology, National Institute of Health, Tokyo, Japan.

PMID: 1406658 PMCID: PMC360402 DOI: 10.1128/mcb.12.10.4751-4757.1992
Free PMC Article

Abstract

A highly malignant human T-cell receptor (TCR) gamma/delta+ T-cell leukemia was shown to have a productive rearrangement of the TCR delta locus on one chromosome 14 and a novel t(8;14)(q24;q11) rearrangement involving the J delta 1 gene segment on the other chromosome 14. Chromosome walking coupled with pulsed-field gel electrophoretic (PFGE) analysis determined that the TCR J delta 1 gene fragment of the involved chromosome was relocated approximately 280 kb downstream of the c-myc proto-oncogene locus found on chromosome band 8q24. This rearrangement was reminiscent of the Burkitt's lymphoma variants that translocate to a region identified as the pvt-1 locus. Sequence comparison of the breakpoint junctions of interchromosomal rearrangements in T-cell leukemias involving the TCR delta-chain locus revealed novel signal-like sequence motifs, GCAGA(A/T)C and CCCA(C/G)GAC. These sequences were found on chromosome 8 at the 5' flanking site of the breakpoint junction of chromosome 8 in the TCR gamma/delta leukemic cells reported here and also on chromosome 1 in T-cell acute lymphocytic leukemia patients carrying the t(1;14)(p32;q11) rearrangement. These results suggest that (i) during early stages of gamma delta T-cell ontogeny, the region 280 kb 3' of the c-myc proto-oncogene on chromosome 8 is fragile and accessible to the lymphoid recombination machinery and (ii) rearrangements to both 8q24 and 1p32 may be governed by novel sequence motifs and be subject to common enzymatic mechanisms.

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