Display options
Share it on

Hua Xi Yi Ke Da Xue Xue Bao. 2002 Jan;33(1):72-4, 120.

[The effects of cholecystokinin octapeptide on PKC activity in rat cerebral cortex neurocytes].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao

[Article in Chinese]
Peng Xiang, Mingjun Qiu, Zeli Du, Manling Chen, Zhaofeng Wu


  1. Lab. of Hormone-receptor, Department of Biochemistry, West China School of Predinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.

PMID: 12599433


OBJECTIVE: To investigate the effects of CCK8 on protein kinase C activity in rat cerebral cortex.

METHODS: The cerebral cortex neurocytes were isolated and used as a model. The effects of CCK8, L-364, 718 and L-365, 260 on PKC activities were detected by using a non-radioactive method.

RESULTS: CCK8 caused a detectable increase in PKC activity at 10(-11) mol/L, and a peak increase of PKC activity was observed at 10(-5) mol/L (about 4.5 U/mg protein). PKC activity was increased in dose-dependent manner by CCK8(10(-11)-10(-6) mol/L). The CCKB-selective receptor antagonist L-365, 260 with a higher efficiency, and the CCKA-selective receptor antagonist L-364, 718 with a lower efficiency were able to block a maximal effect of CCK8-induced PKC activation.

CONCLUSIONS: CCK8 may regulate PKC activities in rat cerebral cortex through CCKB receptor.


MeSH terms

Publication Types