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Petersen KD, Landsfeldt U, Cold GE, et al. ICP is lower during propofol anaesthesia compared to isoflurane and sevoflurane. Acta Neurochir Suppl. 2002;81:89-91doi: 10.1007/978-3-7091-6738-0_24.
Petersen, K. D., Landsfeldt, U., Cold, G. E., Pedersen, C. B., Mau, S., Hauerberg, J., & Holst, P. (2002). ICP is lower during propofol anaesthesia compared to isoflurane and sevoflurane. Acta neurochirurgica. Supplement, 8189-91. https://doi.org/10.1007/978-3-7091-6738-0_24
Petersen, K D, et al. "ICP is lower during propofol anaesthesia compared to isoflurane and sevoflurane." Acta neurochirurgica. Supplement vol. 81 (2002): 89-91. doi: https://doi.org/10.1007/978-3-7091-6738-0_24
Petersen KD, Landsfeldt U, Cold GE, Pedersen CB, Mau S, Hauerberg J, Holst P. ICP is lower during propofol anaesthesia compared to isoflurane and sevoflurane. Acta Neurochir Suppl. 2002;81:89-91. doi: 10.1007/978-3-7091-6738-0_24. PMID: 12168367.
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Acta Neurochir Suppl. 2002;81:89-91. doi: 10.1007/978-3-7091-6738-0_24.

ICP is lower during propofol anaesthesia compared to isoflurane and sevoflurane.

Acta neurochirurgica. Supplement

K D Petersen, U Landsfeldt, G E Cold, C B Pedersen, S Mau, J Hauerberg, P Holst

Affiliations

  1. Department of Anaesthesia and Neurosurgery, Aarhus University Hospital, Denmark.

PMID: 12168367 DOI: 10.1007/978-3-7091-6738-0_24

Abstract

OBJECTIVES: Propofol is a cerebral vasoconstrictor while inhalation anaesthetics like isoflurane and sevoflurane act as cerebral vasodilators in both animal and human studies. This difference of action upon cerebral vessels might implicate a lower ICP during propofol anaesthesia. Cerebral metabolism is decreased by all three anaesthetics. In a prospective, randomised multicenter study ICP was compared during anaesthesia with propofol, isoflurane and sevoflurane.

METHODS: 117 patients subjected to elective craniotomy for supratentorial tumour. Propofol: N = 41; isoflurane: N = 38; sevoflurane: N = 38. Nitrous oxide was omitted and all anaesthetics were supplemented with a continuous infusion of fentanyl. ICP was measured subdurally after removal of the bone flap. MABP, CPP, PCO2, AVDO2, rectal temperature, tumour size and midline shift were registered too.

STATISTICS: Kruskal-Wallis Variance on Ranks. All values in medians with range. P < 0.05 was considered significant.

RESULTS: ICP (mmHg): propofol 7 (-1-20), isoflurane 12 (1-29), sevoflurane 11 (2-32). ICP was significantly lower in the propofol group compared to the isofluane and sevoflurane groups. CPP (mmHg): propofol 80 (45-104), isoflurane 60 (32-84), sevoflurane 63 (44-77). CPP was significantly higher in the propofol group compared to the isoflurane and sevoflurane groups. AVDO2 (mmol/l): propofol 3.1 (0.9-5.1), isoflurane 2.5 (1.1-4.5), sevoflurane 2.6 (0.8-4.1). AVDO2 was significantly higher in the propofol group compared to the isoflurane and sevoflurane groups. No significant differences in PCO2, rectal temperature, tumour size and midline shift were found.

CONCLUSIONS: Subdural ICP is significantly lower during propofol anaesthesia compared to isoflurane and sevoflurane anaesthesia. CPP and AVDO2 are significantly higher during propofol anaesthesia compared to isoflurane and sevoflurane anaesthesia.

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