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Clark AG, Rogers KM. Dependence upon bile volume of the biliary excretion of bromocresol green and amaranth in the anaesthetized rat. Aust J Biol Sci. 1975;28(4):339-51doi: 10.1071/bi9750339.
Clark, A. G., & Rogers, K. M. (1975). Dependence upon bile volume of the biliary excretion of bromocresol green and amaranth in the anaesthetized rat. Australian journal of biological sciences, 28(4), 339-51. https://doi.org/10.1071/bi9750339
Clark, A G, and Rogers, K M. "Dependence upon bile volume of the biliary excretion of bromocresol green and amaranth in the anaesthetized rat." Australian journal of biological sciences vol. 28,4 (1975): 339-51. doi: https://doi.org/10.1071/bi9750339
Clark AG, Rogers KM. Dependence upon bile volume of the biliary excretion of bromocresol green and amaranth in the anaesthetized rat. Aust J Biol Sci. 1975 Aug;28(4):339-51. doi: 10.1071/bi9750339. PMID: 1191126.
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Aust J Biol Sci. 1975 Aug;28(4):339-51. doi: 10.1071/bi9750339.

Dependence upon bile volume of the biliary excretion of bromocresol green and amaranth in the anaesthetized rat.

Australian journal of biological sciences

A G Clark, K M Rogers

PMID: 1191126 DOI: 10.1071/bi9750339

Abstract

The kinetics of the biliary excretion of both bromocresol green and amaranth are better described in terms of rate equations that are functions of the cumulative volume of bile excreted rather than of time. The rate of disappearance of bromocresol green from the liver also appears to depend on the volume of bile excreted rather than on time. It is proposed that bromocresol green, and probably also amaranth, rapidly equilibrates between the hepatic and biliary compartments as a result of reabsorption from the biliary tree and that the rate-limiting factor in the biliary excretion of these dyes is the removal of dye from the biliary tree by bulk flow. Six methods for the graphical presentation of excretion data are examined and their use in the characterization of the kinetics of an excretion system is discussed.

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