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Seiler KU, Wassermann O. Drug-induced phospholipidosis. II. Alterations in the phospholipid pattern of organs from mice, rats and guinea-pigs after chronic treatment with chlorphentermine. Naunyn Schmiedebergs Arch Pharmacol. 1975;288(2):261-8doi: 10.1007/BF00500531.
Seiler, K. U., & Wassermann, O. (1975). Drug-induced phospholipidosis. II. Alterations in the phospholipid pattern of organs from mice, rats and guinea-pigs after chronic treatment with chlorphentermine. Naunyn-Schmiedeberg's archives of pharmacology, 288(2), 261-8. https://doi.org/10.1007/BF00500531
Seiler, K U, and Wassermann, O. "Drug-induced phospholipidosis. II. Alterations in the phospholipid pattern of organs from mice, rats and guinea-pigs after chronic treatment with chlorphentermine." Naunyn-Schmiedeberg's archives of pharmacology vol. 288,2 (1975): 261-8. doi: https://doi.org/10.1007/BF00500531
Seiler KU, Wassermann O. Drug-induced phospholipidosis. II. Alterations in the phospholipid pattern of organs from mice, rats and guinea-pigs after chronic treatment with chlorphentermine. Naunyn Schmiedebergs Arch Pharmacol. 1975;288(2):261-8. doi: 10.1007/BF00500531. PMID: 1161047.
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Naunyn Schmiedebergs Arch Pharmacol. 1975;288(2):261-8. doi: 10.1007/BF00500531.

Drug-induced phospholipidosis. II. Alterations in the phospholipid pattern of organs from mice, rats and guinea-pigs after chronic treatment with chlorphentermine.

Naunyn-Schmiedeberg's archives of pharmacology

K U Seiler, O Wassermann

PMID: 1161047 DOI: 10.1007/BF00500531

Abstract

In three species chronic treatment with the anorectic drug chlorphentermine causes a profound alteration of the phospholipid/lipid metabolism in the organism, resulting in an increase of the fractions of phospholipids and lipids, e.g. in lungs, livers and adrenals. The results are interpreted as drug-induced generalized phospholipidosis, which is caused by amphiphilic drugs, like chlorphentermine and others. Its extent depends on several factors, like content, pattern and turnover rate of phospholipids in different organs, and on the species.

References

  1. J Cell Biol. 1962 Feb;12:221-9 - PubMed
  2. Res Exp Med (Berl). 1973 Nov 23;161(4):272-88 - PubMed
  3. Naunyn Schmiedebergs Arch Pharmacol. 1973;279(2):207-10 - PubMed
  4. Z Kardiol. 1973 Dec;62(12):1090-8 - PubMed
  5. Z Klin Chem Klin Biochem. 1970 Sep;8(5):488-91 - PubMed
  6. J Pharm Pharmacol. 1973 Mar;25(3):239-43 - PubMed
  7. Klin Wochenschr. 1973 Mar 15;51(6):284-5 - PubMed
  8. Beitr Pathol. 1972 Apr;146(1):79-88 - PubMed
  9. Am J Physiol. 1967 Sep;213(3):671-6 - PubMed
  10. J Cell Biol. 1973 Jul;58(1):152-71 - PubMed
  11. Arzneimittelforschung. 1970 Mar;20(3):417 - PubMed
  12. Virchows Arch B Cell Pathol. 1972;11(2):167-81 - PubMed
  13. Tex Rep Biol Med. 1967 Fall;25(3):350-9 - PubMed
  14. Dtsch Med Wochenschr. 1973 Aug 31;98(35):1616 passim - PubMed
  15. Naunyn Schmiedebergs Arch Pharmacol. 1974;282(2):113-22 - PubMed
  16. Arzneimittelforschung. 1972 Dec;22(12):2096-9 - PubMed
  17. Naunyn Schmiedebergs Arch Pharmacol. 1974;283(3):331-4 - PubMed

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