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Younus M, Labellarte MJ. Insomnia in children: when are hypnotics indicated?. Paediatr Drugs. 2002;4(6):391-403doi: 10.2165/00128072-200204060-00006.
Younus, M., & Labellarte, M. J. (2002). Insomnia in children: when are hypnotics indicated?. Paediatric drugs, 4(6), 391-403. https://doi.org/10.2165/00128072-200204060-00006
Younus, Mohammed, and Labellarte, Michael J. "Insomnia in children: when are hypnotics indicated?." Paediatric drugs vol. 4,6 (2002): 391-403. doi: https://doi.org/10.2165/00128072-200204060-00006
Younus M, Labellarte MJ. Insomnia in children: when are hypnotics indicated?. Paediatr Drugs. 2002;4(6):391-403. doi: 10.2165/00128072-200204060-00006. PMID: 12038875.
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Paediatr Drugs. 2002;4(6):391-403. doi: 10.2165/00128072-200204060-00006.

Insomnia in children: when are hypnotics indicated?.

Paediatric drugs

Mohammed Younus, Michael J Labellarte

Affiliations

  1. Division of Child and Adolescent Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-3325, USA.

PMID: 12038875 DOI: 10.2165/00128072-200204060-00006

Abstract

Insomnia in children is a nonspecific impairing symptom that may be the result of normal developmental changes, psychosocial duress, a sleep disorder, a psychiatric disorder, other medical disorders, substance misuse, or an adverse effect of medication. Careful clinical assessment of insomnia in children may include the use of symptom rating scales, laboratory testing, or other medical assessment. Short- and long-term treatment of insomnia in children involves management of etiological factors and associated syndromes. Controlled treatment studies of pediatric insomnia are limited to <10 published studies of psychosocial and/or psychopharmacological treatment in young children. Directive parent education and behavior modification techniques have been effective in short-term treatment of insomnia in young children, and may be the preferred treatment of extrinsic insomnia, as well as an important adjunctive treatment of any insomnia symptoms. Two benzodiazepines [flurazepam and delorazepam (chlordesmethyldiazepam)], one antihistamine (niaprazine) and one phenothiazine [alimemazine (trimeprazine)] have been shown to be effective in the short-term treatment of insomnia in young children, although none of these agents have US Food and Drug Administration approval for pediatric insomnia. Short-acting benzodiazepines may have a role in the brief treatment of pediatric insomnia associated with an anxiety or mood disorder, psychosis, aggression, medication- induced activation, or anticipatory anxiety associated with a medical procedure. However, tachyphylaxis and risk of misuse preclude the long-term use of benzodiazepines for the treatment of insomnia in children. Newer hypnotics, which appear better tolerated than the benzodiazepines in studies of adults, may have a role when combined with psychosocial treatments of pediatric insomnia. Treatment of intrinsic pediatric insomnia may additionally involve chronotherapy or medical management.

References

  1. J Am Acad Child Adolesc Psychiatry. 1997 Sep;36(9):1236-43 - PubMed
  2. Curr Ther Res Clin Exp. 1976 Jan;19(1):99-104 - PubMed
  3. Am J Psychiatry. 1997 Aug;154(8):1057-62 - PubMed
  4. Sleep. 2000 Dec 15;23(8):1043-51 - PubMed
  5. Arch Gen Psychiatry. 1996 Dec;53(12):1090-7 - PubMed
  6. Arq Neuropsiquiatr. 1982 Mar;40(1):1-13 - PubMed
  7. Pediatrics. 1987 Nov;80(5):664-71 - PubMed
  8. J Toxicol Clin Toxicol. 1997;35(5):453-7 - PubMed
  9. J Am Acad Child Adolesc Psychiatry. 1987 May;26(3):449-52 - PubMed
  10. Dev Med Child Neurol. 1996 Apr;38(4):335-44 - PubMed
  11. Drugs. 2000 Apr;59(4):865-89 - PubMed
  12. J Neurol Neurosurg Psychiatry. 2001 Feb;70(2):192-7 - PubMed
  13. Br Med J. 1980 May 10;280(6224):1177-9 - PubMed
  14. J Am Acad Child Adolesc Psychiatry. 1999 Mar;38(3):272-9 - PubMed
  15. Encephale. 1997 Nov-Dec;23(6):447-53 - PubMed
  16. J Am Acad Child Adolesc Psychiatry. 1999 Oct;38(10):1230-6 - PubMed
  17. J Am Acad Child Adolesc Psychiatry. 1992 Jan;31(1):45-9 - PubMed
  18. Pediatr Neurol. 2000 Mar;22(3):182-6 - PubMed
  19. Curr Opin Pulm Med. 1997 Nov;3(6):464-9 - PubMed
  20. Psychiatry Res. 2000 May 15;94(2):93-102 - PubMed
  21. Dialogues Clin Neurosci. 2001 Jun;3(2):79-92 - PubMed
  22. Acta Anaesthesiol Belg. 1977;28(2):123-31 - PubMed
  23. Pediatrics. 1989 Nov;84(5):756-61 - PubMed
  24. J Child Adolesc Psychopharmacol. 2001 Spring;11(1):1-4 - PubMed
  25. Horm Res. 1991;35(1):30-4 - PubMed
  26. West J Med. 2000 Jul;173(1):33-8 - PubMed
  27. J Child Psychol Psychiatry. 1985 Jul;26(4):591-8 - PubMed
  28. Sleep Med. 2000 Feb 1;1(1):21-32 - PubMed
  29. J Sleep Res. 1996 Dec;5(4):251-61 - PubMed
  30. J Psychosom Res. 1998 Dec;45(6):549-55 - PubMed
  31. Lakartidningen. 1999 Nov 24;96(47):5200-6 - PubMed
  32. Child Adolesc Psychiatr Clin N Am. 2000 Jul;9(3):605-46, viii - PubMed
  33. Pediatrics. 1988 Feb;81(2):203-12 - PubMed
  34. Am J Psychiatry. 1994 Feb;151(2):249-53 - PubMed
  35. Pharmacol Res. 1992 Feb-Mar;25 Suppl 1:83-4 - PubMed
  36. J Am Acad Child Adolesc Psychiatry. 2000 Jun;39(6):713-20 - PubMed
  37. Eur Neuropsychopharmacol. 2001 Apr;11(2):153-61 - PubMed
  38. Psychopharmacol Bull. 1985;21(4):995-8 - PubMed
  39. Psychopharmacology (Berl). 1995 Sep;121(2):242-9 - PubMed
  40. J Sleep Res. 1994;3:111-20 - PubMed
  41. Arch Gen Psychiatry. 1985 Oct;42(10):977-83 - PubMed
  42. J Clin Pharmacol. 1990 Nov;30(11):1041-8 - PubMed
  43. J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8 - PubMed
  44. J Dev Behav Pediatr. 2000 Feb;21(1):27-36 - PubMed
  45. J Child Adolesc Psychopharmacol. 1998;8(2):87-97 - PubMed
  46. J Autism Dev Disord. 2000 Apr;30(2):99-111 - PubMed
  47. Brain Dev. 1999 Dec;21(8):548-53 - PubMed
  48. J Child Psychol Psychiatry. 1989 Nov;30(6):913-8 - PubMed
  49. J Child Adolesc Psychopharmacol. 1999;9(3):157-68 - PubMed
  50. Child Adolesc Psychiatr Clin N Am. 2000 Jan;9(1):201-24 - PubMed
  51. Psychiatry Clin Neurosci. 1998 Oct;52(5):483-90 - PubMed
  52. Rev Neurol. 2000 Jan 16-31;30(2):188-91 - PubMed
  53. Arch Gen Psychiatry. 1997 Nov;54(11):1031-7 - PubMed
  54. J Am Acad Child Adolesc Psychiatry. 1997 Jun;36(6):844-52 - PubMed
  55. J Clin Psychiatry. 1999 Aug;60(8):536-44 - PubMed
  56. Clin Ther. 2000 Dec;22(12 ):1443-61 - PubMed
  57. J Am Acad Child Adolesc Psychiatry. 1994 Mar-Apr;33(3):372-6 - PubMed
  58. J Am Acad Child Adolesc Psychiatry. 2001 Jul;40(7):762-72 - PubMed
  59. JAMA. 1992 Jan 1;267(1):77-82 - PubMed
  60. J Dev Behav Pediatr. 1991 Oct;12(5):308-14 - PubMed
  61. Arch Dis Child. 1987 Mar;62(3):253-7 - PubMed
  62. Can J Psychiatry. 1998 Dec;43(10):1050-1 - PubMed
  63. J Child Neurol. 2001 Aug;16(8):581-4 - PubMed
  64. J Child Psychol Psychiatry. 1990 May;31(4):551-67 - PubMed
  65. J Am Acad Child Adolesc Psychiatry. 2000 Apr;39(4):502-8 - PubMed
  66. Am J Gastroenterol. 2000 Oct;95(10):3011-2 - PubMed
  67. J Am Acad Child Adolesc Psychiatry. 1997 Apr;36(4):554-65 - PubMed
  68. J Am Acad Child Adolesc Psychiatry. 1995 May;34(5):649-57 - PubMed
  69. N Engl J Med. 2001 Apr 26;344(17):1279-85 - PubMed
  70. J Paediatr Child Health. 1998 Jun;34(3):263-6 - PubMed
  71. Arch Pediatr Adolesc Med. 1997 May;151(5):473-80 - PubMed
  72. J Am Acad Child Adolesc Psychiatry. 2001 Oct;40(10):1175-81 - PubMed
  73. J Am Acad Child Adolesc Psychiatry. 1989 Jul;28(4):566-73 - PubMed
  74. J Child Adolesc Psychopharmacol. 1997 Summer;7(2):97-107 - PubMed
  75. J Am Acad Child Adolesc Psychiatry. 1996 Oct;35(10):1314-21 - PubMed
  76. Arch Gen Psychiatry. 1991 Apr;48(4):324-8 - PubMed
  77. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):222-9 - PubMed
  78. J Am Acad Child Adolesc Psychiatry. 1998 Feb;37(2):171-8 - PubMed
  79. Folia Psychiatr Neurol Jpn. 1984;38(1):45-51 - PubMed
  80. No To Hattatsu. 1999 Sep;31(5):428-37 - PubMed
  81. Compr Psychiatry. 2000 Jan-Feb;41(1):49-56 - PubMed
  82. J Learn Disabil. 1998 Nov-Dec;31(6):572-8 - PubMed

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