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Sneppen SB, Lange M, Pedersen LM, et al. Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly. Growth Horm IGF Res. 2001;11(6):384-91doi: 10.1054/ghir.2001.0254.
Sneppen, S. B., Lange, M., Pedersen, L. M., Kristensen L, L. �. �., Main, K. M., Juul, A., Skakkebaek, N. E., & Feldt-Rasmussen, U. (2001). Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 11(6), 384-91. https://doi.org/10.1054/ghir.2001.0254
Sneppen, S B, et al. "Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly." Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society vol. 11,6 (2001): 384-91. doi: https://doi.org/10.1054/ghir.2001.0254
Sneppen SB, Lange M, Pedersen LM, Kristensen L LØ, Main KM, Juul A, Skakkebaek NE, Feldt-Rasmussen U. Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly. Growth Horm IGF Res. 2001 Dec;11(6):384-91. doi: 10.1054/ghir.2001.0254. PMID: 11914026.
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Growth Horm IGF Res. 2001 Dec;11(6):384-91. doi: 10.1054/ghir.2001.0254.

Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

S B Sneppen, M Lange, L M Pedersen, L Ø Kristensen L, K M Main, A Juul, N E Skakkebaek, U Feldt-Rasmussen

Affiliations

  1. Department of Endocrinology, Rigshospitalet, Denmark

PMID: 11914026 DOI: 10.1054/ghir.2001.0254

Abstract

The aim was to evaluate, markers of disease activity in acromegaly in relation to perceived disease activity. Thirty-seven consecutively treated, acromegalic patients, classified by clinical symptoms as inactive (n=16), slightly active (n=10) and active (n=11), entered the study. When evaluating the inactive and the active groups, we found that positive and negative predictive values (PV(pos), PV(neg)) for clinical disease activity of total and free insulin-like growth factor-I (IGF-I) were 0.59, 0.90 and 1.00, 0.82 respectively. Acid-labile subunit (ALS) showed diagnostic merit similar to insulin-like growth factor binding protein-3 (IGFBP-3) with PV(pos) of 0.69 and 0.71 and PV(neg) of 0.91 and 0.92 respectively. We conclude that free IGF-I is more closely related than total IGF-I to perceived disease activity and is as such useful when evaluating previously treated acromegaly for disease activity. Total IGF-I, IGFBP-3 and ALS possess a higher PV(neg) for the clinical disease activity. None of the parameters can at present be claimed to be superior to the others and thus all the measured parameters are recommended to be part of the evaluation of acromegalic patients.

Copyright 2001 Elsevier Science Ltd.

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