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Unglaub-Leisten I, Stickl H, Frick E, et al. Chromosomenuntersuchungen an peripheren Lymphozyten bei Patienten mit multipler Sklerose [Chromosomal aberrations in peripheral lymphocytes of patients with multiple sclerosis (author's transl)]. Dtsch Med Wochenschr. 1975;100(40):2028-34doi: 10.1055/s-0028-1106496.
Unglaub-Leisten, I., Stickl, H., Frick, E., Angstwurm, H., & Ring, J. (1975). Chromosomenuntersuchungen an peripheren Lymphozyten bei Patienten mit multipler Sklerose [Chromosomal aberrations in peripheral lymphocytes of patients with multiple sclerosis (author's transl)]. Deutsche medizinische Wochenschrift (1946), 100(40), 2028-34. https://doi.org/10.1055/s-0028-1106496
Unglaub-Leisten, I, et al. "Chromosomenuntersuchungen an peripheren Lymphozyten bei Patienten mit multipler Sklerose" [Chromosomal aberrations in peripheral lymphocytes of patients with multiple sclerosis (author's transl)]. Deutsche medizinische Wochenschrift (1946) vol. 100,40 (1975): 2028-34. doi: https://doi.org/10.1055/s-0028-1106496
Unglaub-Leisten I, Stickl H, Frick E, Angstwurm H, Ring J. Chromosomenuntersuchungen an peripheren Lymphozyten bei Patienten mit multipler Sklerose [Chromosomal aberrations in peripheral lymphocytes of patients with multiple sclerosis (author's transl)]. Dtsch Med Wochenschr. 1975 Oct 03;100(40):2028-34. doi: 10.1055/s-0028-1106496. German. PMID: 1157719.
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Georg Thieme Verlag Stuttgart, New York

Dtsch Med Wochenschr. 1975 Oct 03;100(40):2028-34. doi: 10.1055/s-0028-1106496.

[Chromosomal aberrations in peripheral lymphocytes of patients with multiple sclerosis (author's transl)].

Deutsche medizinische Wochenschrift (1946)

[Article in German]
I Unglaub-Leisten, H Stickl, E Frick, H Angstwurm, J Ring

PMID: 1157719 DOI: 10.1055/s-0028-1106496

Abstract

In chromosomes of peripheral lymphocytes of 35 patients with multiple sclerosis treated with azathioprine, antilymphocytic globulin or thoracic-duct drainage structural aberrations (breaks and gaps) were found at a significantly high rate. The aberration rates were increased in another ten untreated patients as well, but less so. Patients previously treated had a high aberration rate, too. The B- and C-chromosomes of patients treated with azathioprine were more frequently involved than those of control subjects. The terminal segment of the long arm of chromosome 1 was mostly affected in these patients, while in all groups there was an increase of aberrations in the centre of the long arm of the C-chromosome. The clinical significance of these chromosomal aberrations is not yet clear.

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