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Agarwala GC, Mittal RK, Bapat SK, et al. Effect of centrally administered glucagon on urine output in dogs. Indian J Physiol Pharmacol. 1976;20(4):209-15
Agarwala, G. C., Mittal, R. K., Bapat, S. K., & Bharadwaj, U. R. (1976). Effect of centrally administered glucagon on urine output in dogs. Indian journal of physiology and pharmacology, 20(4), 209-15.
Agarwala, G C, et al. "Effect of centrally administered glucagon on urine output in dogs." Indian journal of physiology and pharmacology vol. 20,4 (1976): 209-15.
Agarwala GC, Mittal RK, Bapat SK, Bharadwaj UR. Effect of centrally administered glucagon on urine output in dogs. Indian J Physiol Pharmacol. 1976 Oct-Dec;20(4):209-15. PMID: 1010636.
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Indian J Physiol Pharmacol. 1976 Oct-Dec;20(4):209-15.

Effect of centrally administered glucagon on urine output in dogs.

Indian journal of physiology and pharmacology

G C Agarwala, R K Mittal, S K Bapat, U R Bharadwaj

PMID: 1010636

Abstract

The effect of minimal doses of glucagon, administered by intracerebroventricular (ICV) and intracisternal(IC) routes, on urine output in mongrel dogs have been studied. The dose of 2.0 mug of glucagon was found to be the minimal dose for diuresis on peripheral administration. This dose when centrally administered, produced an oliguric effect in animals. This effect was not observed in vagosympathectomised-spinal cord transectomised or adrenalectomised animals. It is suggested that the probable efferents might be the sympathetic fibres as they are present in vagi nerves as well in the spinal cord (26). The observations made in an attempt to find out the organ responsible for the oliguric effect, showed that some substance released from the adrenal cortex has an influence on the kidney's excretory function.

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