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Isenberg JI, Grossman MI, Maxwell V, et al. Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer. J Clin Invest. 1975;55(2):330-7doi: 10.1172/JCI107936.
Isenberg, J. I., Grossman, M. I., Maxwell, V., & Walsh, J. H. (1975). Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer. The Journal of clinical investigation, 55(2), 330-7. https://doi.org/10.1172/JCI107936
Isenberg, J I, et al. "Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer." The Journal of clinical investigation vol. 55,2 (1975): 330-7. doi: https://doi.org/10.1172/JCI107936
Isenberg JI, Grossman MI, Maxwell V, Walsh JH. Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer. J Clin Invest. 1975 Feb;55(2):330-7. doi: 10.1172/JCI107936. PMID: 1127103; PMCID: PMC301751.
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American Society for Clinical Investigation Free PMC Article

J Clin Invest. 1975 Feb;55(2):330-7. doi: 10.1172/JCI107936.

Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer.

The Journal of clinical investigation

J I Isenberg, M I Grossman, V Maxwell, J H Walsh

PMID: 1127103 PMCID: PMC301751 DOI: 10.1172/JCI107936
Free PMC Article

Abstract

The effect of graded doses of pentagastrin (2.7-6,000 ng/kg times h) on gastric acid secretion was measured in 20 duodenal ulcer (DU) and 20 non-DU subjects. Confirming many previous studies, the mean observed highest response and the mean calculated maximal response were significantly greater in DU than in non-DU subjects. The mean dose (plus or minus SE) in ng/kg times h for half maximal response, calculated from responses corrected for basal secretion and normalized for maximal secretion, was 92.1 plus or minus 1.7 in DU and 246.8 plus or minus 24.6 in non-DU subjects, a significant difference. By parallel line bioassay non-DU subjects required 2.8 times more pentagastrin (95% confidence limits 2.1-3.7) than DU highest response. Thus, this study shows that, compared with non-DU subjects, DU patients not only secrete more acid in response to stimulation by pentagastrin but also are more sensitive to stimulation by pentagastrin, that is, need smaller doses to achieve the same fraction of maximal response.

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