Display options
Cite
Buring K. On the origin of cells in heterotopic bone formation. Clin Orthop Relat Res. 1975;(110):293-301doi: 10.1097/00003086-197507000-00040.
Buring, K. (1975). On the origin of cells in heterotopic bone formation. Clinical orthopaedics and related research, (110), 293-301. https://doi.org/10.1097/00003086-197507000-00040
Buring, K. "On the origin of cells in heterotopic bone formation." Clinical orthopaedics and related research vol. ,110 (1975): 293-301. doi: https://doi.org/10.1097/00003086-197507000-00040
Buring K. On the origin of cells in heterotopic bone formation. Clin Orthop Relat Res. 1975 Jul-Aug;(110):293-301. doi: 10.1097/00003086-197507000-00040. PMID: 1157392.
Copy Download .nbib Format: NLM
Share it on

Clin Orthop Relat Res. 1975 Jul-Aug;(110):293-301. doi: 10.1097/00003086-197507000-00040.

On the origin of cells in heterotopic bone formation.

Clinical orthopaedics and related research

K Buring

PMID: 1157392 DOI: 10.1097/00003086-197507000-00040

Abstract

Previous experiments have demonstrated that decalcified, lyophilized bone matrix is a powerful substratum for differentiation of mesenchymal cells into new bone. The present experiment employs parabiosis as a tool to distinguish between cells of hemotogenous origin and mesenchymal cell populations derived from the site of implantation of bone matrix. The results indicate that the osteoinductor releasing cells are blood-borne monocytoid cells which enter the tissues by diapedesis and become histiocytes, macrophages, matrixclasts and osteoclasts; their precursors are derived from bone marrow at sites remote from the area of bone induction. The cell populations responding to the osteoinductor released by this mechanism develop into osteoblasts and osteocytes and are the progeny of perivascular mesenchymal cells.

Cited by

MeSH terms

Publication Types

LinkOut - more resources