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Alexander K, Akhtar M. The role of a 5alpha-hydroxylated intermediate in the formation of the 5, 6-double bond in cholesterol biosynthesis. Biochem J. 1975;145(2):345-52doi: 10.1042/bj1450345.
Alexander, K., & Akhtar, M. (1975). The role of a 5alpha-hydroxylated intermediate in the formation of the 5, 6-double bond in cholesterol biosynthesis. The Biochemical journal, 145(2), 345-52. https://doi.org/10.1042/bj1450345
Alexander, K, and Akhtar, M. "The role of a 5alpha-hydroxylated intermediate in the formation of the 5, 6-double bond in cholesterol biosynthesis." The Biochemical journal vol. 145,2 (1975): 345-52. doi: https://doi.org/10.1042/bj1450345
Alexander K, Akhtar M. The role of a 5alpha-hydroxylated intermediate in the formation of the 5, 6-double bond in cholesterol biosynthesis. Biochem J. 1975 Feb;145(2):345-52. doi: 10.1042/bj1450345. PMID: 1156363; PMCID: PMC1165223.
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Biochem J. 1975 Feb;145(2):345-52. doi: 10.1042/bj1450345.

The role of a 5alpha-hydroxylated intermediate in the formation of the 5, 6-double bond in cholesterol biosynthesis.

The Biochemical journal

K Alexander, M Akhtar

PMID: 1156363 PMCID: PMC1165223 DOI: 10.1042/bj1450345
Free PMC Article

Abstract

If the biological conversion of cholest-7-en-3beta-ol (I) into cholesterol (IV) occurred thorugh the intermediacy of cholest-7-ene-3beta,5alpha-diol (II) then the factor(s) adversely affecting the convwesion of the 5alpha-hydroxy sterol (II) into cholesterol must at least equally adversely affect the formation of cholesterol from cholest-7-en-3beta-ol. By using partial denaturation techniquws and dual-labelled precursors it was shown that the enzyme system responsible for the conversion of the 5alpha-hydroxy sterol (II) into cholesterol denatured faster than that for the corresponding conversion from cholest-7-en-3beta-ol (I).

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