Display options
Share it on

J Clin Pathol. 2001 Dec;54(12):897-910. doi: 10.1136/jcp.54.12.897.

Neuroblastoma tumour genetics: clinical and biological aspects.

Journal of clinical pathology

N Bown

Affiliations

  1. School of Biochemistry and Genetics, University of Newcastle upon Tyne/Northern Genetics Service, Royal Victoria Infirmary, 19/20 Claremont Place, Newcastle upon Tyne NE2 4AA, UK. [email protected]

PMID: 11729208 PMCID: PMC1731335 DOI: 10.1136/jcp.54.12.897

Abstract

Neuroblastoma tumour cells show complex combinations of acquired genetic aberrations, including ploidy changes, deletions of chromosome arms 1p and 11q, amplification of the MYCN oncogene, and-most frequently-gains of chromosome arm 17q. Despite intensive investigation, the fundamental role of these features in neuroblastoma initiation and progression remains to be understood. Nonetheless, great progress has been made in relating tumour genetic abnormalities to tumour behaviour and to clinical outcome; indeed, neuroblastoma provides a paradigm for the clinical importance of tumour genetic abnormalities. Knowledge of MYCN status is increasingly being used in treatment decisions for individual children, and the clinical value of 1p and 17q data as adjuncts or refinements in risk stratification is under active investigation. Reliable detection of these molecular cytogenetic features should be regarded as mandatory for all new cases at presentation.

References

  1. J Pediatr Surg. 1991 Jul;26(7):834-7 - PubMed
  2. Hum Mol Genet. 1995 Apr;4(4):535-9 - PubMed
  3. Science. 1984 Jun 8;224(4653):1121-4 - PubMed
  4. Ann Oncol. 1999 Jun;10(6):715-21 - PubMed
  5. J Clin Oncol. 2000 May;18(9):1888-99 - PubMed
  6. Genes Chromosomes Cancer. 1993 May;7(1):32-7 - PubMed
  7. J Clin Oncol. 1998 Apr;16(4):1256-64 - PubMed
  8. Genes Chromosomes Cancer. 1994 Aug;10(4):275-81 - PubMed
  9. Pediatr Pathol Lab Med. 1997 Nov-Dec;17(6):875-83 - PubMed
  10. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5520-4 - PubMed
  11. Mol Cell Biol. 1989 Nov;9(11):4903-13 - PubMed
  12. Nature. 1984 Mar 15-21;308(5956):288-91 - PubMed
  13. Mutat Res. 1992 May;276(3):291-7 - PubMed
  14. Br J Cancer. 1996 Nov;74(10):1620-6 - PubMed
  15. Cell Growth Differ. 1991 May;2(5):245-55 - PubMed
  16. J Clin Oncol. 1998 Oct;16(10):3286-94 - PubMed
  17. Am J Hum Genet. 1993 Jan;52(1):176-82 - PubMed
  18. Genes Chromosomes Cancer. 1999 Sep;26(1):40-6 - PubMed
  19. Genes Chromosomes Cancer. 1997 Jul;19(3):176-84 - PubMed
  20. Cancer Genet Cytogenet. 1997 Jul 15;96(2):134-9 - PubMed
  21. Med Pediatr Oncol. 1995 Apr;24(4):215-21 - PubMed
  22. Cancer Genet Cytogenet. 1993 Sep;69(2):166-7 - PubMed
  23. Anticancer Res. 1998 Mar-Apr;18(2A):1211-5 - PubMed
  24. Am J Pathol. 2001 May;158(5):1579-84 - PubMed
  25. Cancer. 1999 Jul 15;86(2):349-63 - PubMed
  26. Br J Cancer. 1994 Mar;69(3):445-51 - PubMed
  27. Proc Natl Acad Sci U S A. 1983 Jul;80(13):4069-73 - PubMed
  28. Oncogene. 2000 Feb 3;19(5):617-23 - PubMed
  29. Br J Cancer. 1999 Dec;81(8):1402-9 - PubMed
  30. Lab Invest. 1993 Jul;69(1):43-50 - PubMed
  31. Eur J Cancer. 1997 Oct;33(12):2101-5 - PubMed
  32. Am J Hum Genet. 1994 Aug;55(2):334-40 - PubMed
  33. Cancer Genet Cytogenet. 2000 Jul 1;120(1):44-9 - PubMed
  34. Mol Diagn. 1996 Dec;1(4):281-289 - PubMed
  35. Med Pediatr Oncol. 2000 Dec;35(6):544-6 - PubMed
  36. Eur J Cancer. 1997 Oct;33(12):2043-9 - PubMed
  37. Histol Histopathol. 1998 Apr;13(2):425-35 - PubMed
  38. Eur J Cancer. 1995;31A(4):530-5 - PubMed
  39. J Pediatr. 1975 Nov;87(5):763-5 - PubMed
  40. N Engl J Med. 1993 Mar 25;328(12):847-54 - PubMed
  41. Nat Med. 2000 May;6(5):529-35 - PubMed
  42. Eur J Cancer. 1997 Oct;33(12):1979-82 - PubMed
  43. Br J Cancer. 1998 Jun;77(12):2223-9 - PubMed
  44. Oncogene. 1993 Apr;8(4):855-65 - PubMed
  45. J Cancer Res Clin Oncol. 1986;111(3):266-72 - PubMed
  46. J Pediatr Hematol Oncol. 1997 Mar-Apr;19(2):93-101 - PubMed
  47. Cell. 1983 Dec;35(2 Pt 1):359-67 - PubMed
  48. Oncogene. 1995 Mar 16;10(6):1087-93 - PubMed
  49. J Pediatr Surg. 1998 Nov;33(11):1695-8 - PubMed
  50. J Pathol. 1997 Apr;181(4):394-400 - PubMed
  51. Genes Chromosomes Cancer. 2000 Jul;28(3):276-84 - PubMed
  52. Cancer. 1999 Jul 15;86(2):364-72 - PubMed
  53. Cancer Res. 1995 Nov 15;55(22):5366-9 - PubMed
  54. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5523-7 - PubMed
  55. Oncogene. 1992 Jun;7(6):1185-9 - PubMed
  56. Genes Chromosomes Cancer. 1997 Mar;18(3):162-9 - PubMed
  57. Nat Genet. 1993 Jun;4(2):187-90 - PubMed
  58. Cancer. 1986 Jul 15;58(2 Suppl):541-5 - PubMed
  59. Cancer. 1989 Jan 1;63(1):126-32 - PubMed
  60. Nature. 1985 Jul 11-17;316(6024):160-2 - PubMed
  61. Nat Genet. 1998 Sep;20(1):66-9 - PubMed
  62. Eur J Cancer. 2000 May;36(7):901-8 - PubMed
  63. Cancer Genet Cytogenet. 1997 Nov;99(1):19-23 - PubMed
  64. J Clin Pathol. 1993 Dec;46(12):1101-4 - PubMed
  65. Int J Cancer. 1999 Jan 5;80(1):54-9 - PubMed
  66. Cancer Genet Cytogenet. 1982 Nov;7(3):227-30 - PubMed
  67. Med Pediatr Oncol. 2001 Jan;36(1):14-9 - PubMed
  68. J Natl Cancer Inst. 1976 Sep;57(3):683-95 - PubMed
  69. Cancer Genet Cytogenet. 1982 Sep;7(1):33-42 - PubMed
  70. Cancer. 1993 Nov 1;72(9):2763-8 - PubMed
  71. Lancet. 1965 Jul 10;1(7402):55-8 - PubMed
  72. J Med Genet. 1980 Dec;17(6):477-8 - PubMed
  73. Eur J Cancer. 1995;31A(4):541-4 - PubMed
  74. Cancer Genet Cytogenet. 2000 Jan 1;116(1):87-8 - PubMed
  75. Oncogene. 1995 Nov 2;11(9):1829-34 - PubMed
  76. Genes Chromosomes Cancer. 1989 Sep;1(1):67-78 - PubMed
  77. Genes Chromosomes Cancer. 1994 May;10(1):30-9 - PubMed
  78. Hum Genet. 1996 Jun;97(6):834-7 - PubMed
  79. N Engl J Med. 1996 Jan 25;334(4):231-8 - PubMed
  80. Eur J Cancer. 1997 Aug;33(9):1430-7; discussion 1437-8 - PubMed
  81. Genes Chromosomes Cancer. 1992 Sep;5(2):141-9 - PubMed
  82. Br J Cancer. 1988 Jan;57(1):121-6 - PubMed
  83. Med Pediatr Oncol. 2000 Dec;35(6):541-3 - PubMed
  84. J Clin Oncol. 1991 Apr;9(4):581-91 - PubMed
  85. Proc Natl Acad Sci U S A. 1985 Jun;82(11):3736-40 - PubMed
  86. Eur J Cancer. 1997 Oct;33(12):1917-22 - PubMed
  87. J Med Genet. 1997 Nov;34(11):949-51 - PubMed
  88. Eur J Cancer. 1999 Dec;35(14):1895-904 - PubMed
  89. Med Pediatr Oncol. 2000 Dec;35(6):526-30 - PubMed
  90. Am J Pathol. 1990 May;136(5):1043-52 - PubMed
  91. Genes Chromosomes Cancer. 1990 Sep;2(3):252-4 - PubMed
  92. N Engl J Med. 1985 Oct 31;313(18):1111-6 - PubMed
  93. Proc Natl Acad Sci U S A. 1985 Jun;82(11):3761-5 - PubMed
  94. Oncogene. 1999 Jan 7;18(1):233-8 - PubMed
  95. Eur J Cancer. 1997 Oct;33(12):2098-100 - PubMed
  96. Genes Chromosomes Cancer. 1996 Aug;16(4):211-29 - PubMed
  97. Cancer Res. 1992 Apr 1;52(7):1780-5 - PubMed
  98. Jinrui Idengaku Zasshi. 1980 Mar;25(1):39-45 - PubMed
  99. Int J Cancer. 1992 Oct 21;52(4):544-8 - PubMed
  100. J Clin Invest. 1991 Jul;88(1):341-5 - PubMed
  101. Oncogene. 1995 Mar 16;10(6):1081-6 - PubMed
  102. Br J Cancer. 1998 Jun;77(11):1787-91 - PubMed
  103. Eur J Cancer. 1997 Sep;33(10):1627-33 - PubMed
  104. N Engl J Med. 1984 Jul 26;311(4):231-5 - PubMed
  105. Genes Chromosomes Cancer. 1994 Jun;10(2):103-14 - PubMed
  106. Eur J Cancer. 1995;31A(4):535-8 - PubMed
  107. J Clin Oncol. 2000 Mar;18(6):1260-8 - PubMed
  108. Cancer Res. 1989 Mar 1;49(5):1095-8 - PubMed
  109. J Clin Oncol. 1999 Jul;17(7):2264-79 - PubMed
  110. Med Pediatr Oncol. 2001 Jan;36(1):5-10 - PubMed
  111. Cancer. 1977 Nov;40(5):2256-63 - PubMed
  112. Genes Chromosomes Cancer. 1996 May;16(1):40-5 - PubMed
  113. Cancer Res. 1987 Jan 1;47(1):311-8 - PubMed
  114. EMBO J. 1997 Jun 2;16(11):2985-95 - PubMed
  115. Cancer. 1986 Dec 1;58(11):2453-8 - PubMed
  116. N Engl J Med. 1999 Jun 24;340(25):1954-61 - PubMed
  117. Cancer. 1999 Apr 25;87(2):60-8 - PubMed
  118. Cancer Res. 1984 Nov;44(11):5444-9 - PubMed
  119. Med Pediatr Oncol. 2000 Dec;35(6):538-40 - PubMed
  120. Int J Cancer. 2001 Mar 1;91(5):680-6 - PubMed
  121. Eur J Cancer. 2000 Mar;36(4):508-13 - PubMed
  122. Am J Pathol. 1997 Jan;150(1):81-9 - PubMed
  123. Cancer Genet Cytogenet. 1986 Apr 15;21(4):279-85 - PubMed
  124. Genes Chromosomes Cancer. 1996 Nov;17(3):156-65 - PubMed
  125. Br J Cancer. 2000 Nov;83(10):1295-300 - PubMed
  126. J Pediatr Surg. 1989 Feb;24(2):204-7 - PubMed
  127. Oncogene. 1999 Sep 2;18(35):4948-57 - PubMed
  128. Nature. 1994 Aug 4;370(6488):335-6 - PubMed
  129. Genes Chromosomes Cancer. 1998 Oct;23(2):116-22 - PubMed
  130. Genes Chromosomes Cancer. 1999 Jul;25(3):261-9 - PubMed
  131. Genes Chromosomes Cancer. 1998 Oct;23(2):141-52 - PubMed
  132. Eur J Cancer. 1997 Oct;33(12):1932-6 - PubMed
  133. Med Pediatr Oncol. 2000 Dec;35(6):531-3 - PubMed
  134. Am J Med Genet. 1995 Jul 31;58(1):46-9 - PubMed
  135. J Pediatr Surg. 1987 Oct;22(10):895-8 - PubMed
  136. Cytogenet Cell Genet. 1993;63(1):24-8 - PubMed
  137. Med Pediatr Oncol. 2000 Dec;35(6):522-5 - PubMed
  138. Am J Hum Genet. 1994 Aug;55(2):341-7 - PubMed
  139. Proc Natl Acad Sci U S A. 1989 May;86(10):3753-7 - PubMed
  140. Am J Hum Genet. 1990 May;46(5):857-73 - PubMed
  141. Cancer Res. 1995 Aug 15;55(16):3471-4 - PubMed
  142. Genes Chromosomes Cancer. 2001 Jan;30(1):87-90 - PubMed
  143. Am J Pathol. 1993 May;142(5):1339-46 - PubMed
  144. N Engl J Med. 1996 Jan 25;334(4):225-30 - PubMed
  145. Oncogene. 1995 Jan 19;10(2):291-7 - PubMed
  146. Cancer Res. 1987 Aug 15;47(16):4248-53 - PubMed
  147. Curr Biol. 1998 Mar 26;8(7):377-85 - PubMed
  148. Genes Chromosomes Cancer. 1997 Jul;19(3):143-9 - PubMed
  149. Nature. 1983 Sep 15-21;305(5931):245-8 - PubMed

Substances

MeSH terms

Publication Types