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Morando L, Cesa R, Rasetti R, et al. Role of glutamate delta -2 receptors in activity-dependent competition between heterologous afferent fibers. Proc Natl Acad Sci U S A. 2001;98(17):9954-9doi: 10.1073/pnas.171098398.
Morando, L., Cesa, R., Rasetti, R., Harvey, R., & Strata, P. (2001). Role of glutamate delta -2 receptors in activity-dependent competition between heterologous afferent fibers. Proceedings of the National Academy of Sciences of the United States of America, 98(17), 9954-9. https://doi.org/10.1073/pnas.171098398
Morando, L, et al. "Role of glutamate delta -2 receptors in activity-dependent competition between heterologous afferent fibers." Proceedings of the National Academy of Sciences of the United States of America vol. 98,17 (2001): 9954-9. doi: https://doi.org/10.1073/pnas.171098398
Morando L, Cesa R, Rasetti R, Harvey R, Strata P. Role of glutamate delta -2 receptors in activity-dependent competition between heterologous afferent fibers. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9954-9. doi: 10.1073/pnas.171098398. Epub 2001 Aug 07. PMID: 11493687; PMCID: PMC55559.
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Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9954-9. doi: 10.1073/pnas.171098398. Epub 2001 Aug 07.

Role of glutamate delta -2 receptors in activity-dependent competition between heterologous afferent fibers.

Proceedings of the National Academy of Sciences of the United States of America

L Morando, R Cesa, R Rasetti, R Harvey, P Strata

Affiliations

  1. Rita Levi Montalcini Center for Brain Repair, Department of Neuroscience, University of Turin, Torino, Italy.

PMID: 11493687 PMCID: PMC55559 DOI: 10.1073/pnas.171098398

Abstract

A principle that regulates detailed architecture in the brain is that active terminals have a competitive advantage over less active terminals in establishing synaptic connections. This principle is known to apply to fibers within a single neuronal population competing for a common target domain. Here we uncover an additional rule that applies when two neuronal populations compete for two contiguous territories. The cerebellar Purkinje cell dendrites have two different synaptic domains with spines innervated by two separate excitatory inputs, parallel fibers (PFs) and climbing fibers (CFs). Glutamate delta-2 receptors are normally present only on the PF spines where they are important for their innervation. After block of activity by tetrodotoxin, numerous new spines form in the CF domain and become innervated mainly by PFs; all spines, including those still innervated by the CFs, bear delta-2 receptors. Thus, in the absence of activity, PFs gain a competitive advantage over CFs. The entire dendritic arbor becomes a uniform territory with the molecular cues associated with the PFs. To access their proper territory and maintain synaptic contacts, CFs must be active and locally repress the cues of the competitor afferents.

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