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Koo A, Liang IY, Cheng KK. Hepatic sinusoidal responses to intraportal injections of phenylephrine and isoprenaline in the rat. Clin Exp Pharmacol Physiol. 1976;3(4):391-5doi: 10.1111/j.1440-1681.1976.tb00616.x.
Koo, A., Liang, I. Y., & Cheng, K. K. (1976). Hepatic sinusoidal responses to intraportal injections of phenylephrine and isoprenaline in the rat. Clinical and experimental pharmacology & physiology, 3(4), 391-5. https://doi.org/10.1111/j.1440-1681.1976.tb00616.x
Koo, A, et al. "Hepatic sinusoidal responses to intraportal injections of phenylephrine and isoprenaline in the rat." Clinical and experimental pharmacology & physiology vol. 3,4 (1976): 391-5. doi: https://doi.org/10.1111/j.1440-1681.1976.tb00616.x
Koo A, Liang IY, Cheng KK. Hepatic sinusoidal responses to intraportal injections of phenylephrine and isoprenaline in the rat. Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):391-5. doi: 10.1111/j.1440-1681.1976.tb00616.x. PMID: 975627.
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Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):391-5. doi: 10.1111/j.1440-1681.1976.tb00616.x.

Hepatic sinusoidal responses to intraportal injections of phenylephrine and isoprenaline in the rat.

Clinical and experimental pharmacology & physiology

A Koo, I Y Liang, K K Cheng

PMID: 975627 DOI: 10.1111/j.1440-1681.1976.tb00616.x

Abstract

1. Specific alpha- and beta-adrenoreceptor agonists, phenylephrine and isoprenaline, were injected intraportally into the intact rat liver under direct microscopic observation by an in vivo transillumination technique. 2. The diameter of a hepatic sinusoid and the intra-sinusoidal erythrocyte velocity were quantitatively measured, and the sinusoidal volume flow was calculated from these two parameters. 3. Results show that phenylephrine causes a sinusoidal constriction and an increased sinusoidal blood flow, whereas isoprenaline causes the opposite effects on the sinusoids. 4. All the sinusoidal responses to phenylephrine and isoprenaline were dose-dependent and were possibly related to the direct effect of these drugs on the sinusoids.

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