Display options
Cite
Westergaard T, Mortensen PB, Pedersen CB, et al. Søskendeflokkarakteristika, influenza og skizofrenirisiko. Et populationsbaseret kohortestudie. [Sibships characteristics, influenza and risk of schizophrenia. A population-based cohort study]. Ugeskr Laeger. 2001;163(35):4745-9
Westergaard, T., Mortensen, P. B., Pedersen, C. B., Wohlfahrt, J., & Melbye, M. (2001). Søskendeflokkarakteristika, influenza og skizofrenirisiko. Et populationsbaseret kohortestudie. [Sibships characteristics, influenza and risk of schizophrenia. A population-based cohort study]. Ugeskrift for laeger, 163(35), 4745-9.
Westergaard, T, et al. "Søskendeflokkarakteristika, influenza og skizofrenirisiko. Et populationsbaseret kohortestudie." [Sibships characteristics, influenza and risk of schizophrenia. A population-based cohort study]. Ugeskrift for laeger vol. 163,35 (2001): 4745-9.
Westergaard T, Mortensen PB, Pedersen CB, Wohlfahrt J, Melbye M. Søskendeflokkarakteristika, influenza og skizofrenirisiko. Et populationsbaseret kohortestudie. [Sibships characteristics, influenza and risk of schizophrenia. A population-based cohort study]. Ugeskr Laeger. 2001 Aug 27;163(35):4745-9. Danish. PMID: 11572050.
Copy Download .nbib Format: NLM
Share it on

Ugeskr Laeger. 2001 Aug 27;163(35):4745-9.

[Sibships characteristics, influenza and risk of schizophrenia. A population-based cohort study].

Ugeskrift for laeger

[Article in Danish]
T Westergaard, P B Mortensen, C B Pedersen, J Wohlfahrt, M Melbye

Affiliations

  1. Statens Serum Institut, afdeling for epidemiologisk forskning. [email protected]

PMID: 11572050

Abstract

INTRODUCTION: To address the hypothesis that infections, perhaps prenatal exposure to influenza virus, might increase the risk of schizophrenia we studied the possible association between schizophrenia risk and birth order, sibship size, interval between siblings, and influenza prevalence.

MATERIAL AND METHODS: We established a population-based cohort of 1,746,366 persons born to Danish woman who themselves were born since 1935 using data from the Civil Registration System. Schizophrenia in cohort members (n = 2669) and their parents was identified by linkage with the Danish Psychiatric Case Register. Influenza notifications per month in Denmark were obtained from the National Board of Health and Statens Serum Institut.

RESULTS: We found no association between birth order and schizophrenia risk or between schizophrenia risk and influenza prevalence during any month of prenatal life. Coming from a large sibship and having a short interval to the nearest older or younger sibling was associated with an increased risk of schizophrenia.

DISCUSSION: Our findings do not add support to the hypothesis that schizophrenia is associated with prenatal exposure to influenza virus or other common infections, but are compatible with the hypothesis that environmental exposure, perhaps to common infections in childhood, may be a risk factor.

MeSH terms

Publication Types