Display options
Cite
Kienbaum P, Karlssonn T, Sverrisdottir YB, et al. Two sites for modulation of human sympathetic activity by arterial baroreceptors?. J Physiol. 2001;531:861-9doi: 10.1111/j.1469-7793.2001.0861h.x.
Kienbaum, P., Karlssonn, T., Sverrisdottir, Y. B., Elam, M., & Wallin, B. G. (2001). Two sites for modulation of human sympathetic activity by arterial baroreceptors?. The Journal of physiology, 531861-9. https://doi.org/10.1111/j.1469-7793.2001.0861h.x
Kienbaum, P, et al. "Two sites for modulation of human sympathetic activity by arterial baroreceptors?." The Journal of physiology vol. 531 (2001): 861-9. doi: https://doi.org/10.1111/j.1469-7793.2001.0861h.x
Kienbaum P, Karlssonn T, Sverrisdottir YB, Elam M, Wallin BG. Two sites for modulation of human sympathetic activity by arterial baroreceptors?. J Physiol. 2001 Mar 15;531:861-9. doi: 10.1111/j.1469-7793.2001.0861h.x. PMID: 11251065; PMCID: PMC2278508.
Copy Download .nbib Format: NLM
Share it on

J Physiol. 2001 Mar 15;531:861-9. doi: 10.1111/j.1469-7793.2001.0861h.x.

Two sites for modulation of human sympathetic activity by arterial baroreceptors?.

The Journal of physiology

P Kienbaum, T Karlssonn, Y B Sverrisdottir, M Elam, B G Wallin

Affiliations

  1. Institute of Clinical Neuroscience, Unit of Clinical Neurophysiology, Sahlgren Hospital, University of Göteborg, Sweden.

PMID: 11251065 PMCID: PMC2278508 DOI: 10.1111/j.1469-7793.2001.0861h.x

Abstract

1. Peroneal muscle sympathetic nerve activity (MSA), finger blood pressure and cardiac intervals were recorded at rest in 60 healthy subjects, aged 18-71 years. Arterial baroreflex control of MSA was analysed by relating each spontaneous sympathetic burst to the diastolic blood pressure and the cardiac interval of the heart beat during which the burst was generated. The results were expressed as blood pressure/cardiac interval threshold for occurrence of bursts, and as baroreflex sensitivity (i.e. the relationship between diastolic pressure/cardiac interval and burst strength). 2. Significant blood pressure/cardiac interval thresholds were present in all subjects and old subjects had less variability of thresholds than young subjects. In contrast, significant baroreflex sensitivity for diastolic pressure and cardiac interval was present in only 55 and 73 % of the subjects, respectively. There was no age-related difference in sensitivity. 3. In 40 subjects, two 5 min periods from the same recording were analysed. The number of sympathetic bursts and the threshold for occurrence of bursts were reproducible in all subjects. In contrast, significant baroreflex sensitivity in both periods was present in only 30 % (diastolic pressure) and 40 % (cardiac interval) of the subjects. 4. The results show that the baroreflex mechanisms regulating the occurrence and strength of sympathetic bursts are not identical. We suggest that the modulation occurs at two sites, one which determines whether or not a burst will occur, and another at which the strength of the discharge is determined.

References

  1. Circulation. 2000 Oct 24;102(17):2076-81 - PubMed
  2. Acta Physiol Scand. 1972 Jan;84(1):65-81 - PubMed
  3. Pflugers Arch. 1975 Jul 21;358(2):101-10 - PubMed
  4. J Physiol. 1977 Nov;272(2):383-97 - PubMed
  5. J Physiol. 1978 Jan;274:621-37 - PubMed
  6. Hypertension. 1979 Mar-Apr;1(2):67-77 - PubMed
  7. Am J Physiol. 1982 Feb;242(2):H185-90 - PubMed
  8. Hypertension. 1989 Jun;13(6 Pt 1):647-55 - PubMed
  9. Am J Physiol. 1989 Nov;257(5 Pt 1):E654-64 - PubMed
  10. Cardiovasc Res. 1990 Mar;24(3):214-21 - PubMed
  11. Am J Cardiol. 1992 Feb 15;69(5):523-31 - PubMed
  12. J Auton Nerv Syst. 1992 Jan;37(1):19-28 - PubMed
  13. Am J Physiol. 1992 Sep;263(3 Pt 2):H798-803 - PubMed
  14. Am J Physiol. 1992 Oct;263(4 Pt 2):H1311-7 - PubMed
  15. Clin Auton Res. 1993 Jun;3(3):201-5 - PubMed
  16. Anesthesiology. 1994 Mar;80(3):534-44 - PubMed
  17. Anesthesiology. 1995 Apr;82(4):919-25 - PubMed
  18. Circulation. 1995 Dec 1;92(11):3206-11 - PubMed
  19. J Physiol. 1996 Aug 15;495 ( Pt 1):279-88 - PubMed
  20. J Auton Nerv Syst. 1996 Sep 12;60(3):209-12 - PubMed
  21. Am J Respir Crit Care Med. 1996 Nov;154(5):1490-6 - PubMed
  22. Am J Hypertens. 1997 Feb;10(2):162-7 - PubMed
  23. Clin Exp Pharmacol Physiol. 1997 Nov;24(11):791-9 - PubMed
  24. Hypertension. 1997 Nov;30(5):1089-96 - PubMed
  25. J Auton Nerv Syst. 1998 May 28;70(1-2):32-7 - PubMed
  26. Am J Physiol. 1998 Sep;275(3 Pt 2):F441-6 - PubMed
  27. J Physiol. 1999 Apr 1;516 ( Pt 1):303-14 - PubMed
  28. Am J Physiol. 1999 May;276(5 Pt 2):H1691-8 - PubMed

MeSH terms

Publication Types