Display options
Cite
Mazat L, Lafont S, Berr C, et al. Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci U S A. 2001;98(14):8145-50doi: 10.1073/pnas.121177998.
Mazat, L., Lafont, S., Berr, C., Debuire, B., Tessier, J. F., Dartigues, J. F., & Baulieu, E. E. (2001). Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proceedings of the National Academy of Sciences of the United States of America, 98(14), 8145-50. https://doi.org/10.1073/pnas.121177998
Mazat, L, et al. "Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality." Proceedings of the National Academy of Sciences of the United States of America vol. 98,14 (2001): 8145-50. doi: https://doi.org/10.1073/pnas.121177998
Mazat L, Lafont S, Berr C, Debuire B, Tessier JF, Dartigues JF, Baulieu EE. Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci U S A. 2001 Jul 03;98(14):8145-50. doi: 10.1073/pnas.121177998. Epub 2001 Jun 26. PMID: 11427700; PMCID: PMC35482.
Copy Download .nbib Format: NLM
Share it on

Proc Natl Acad Sci U S A. 2001 Jul 03;98(14):8145-50. doi: 10.1073/pnas.121177998. Epub 2001 Jun 26.

Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality.

Proceedings of the National Academy of Sciences of the United States of America

L Mazat, S Lafont, C Berr, B Debuire, J F Tessier, J F Dartigues, E E Baulieu

Affiliations

  1. Institut National de la Santé et de la Recherche Médicale U330, Epidémiologie, Santé Publique et Développement, Université de Bordeaux II, 146, Rue Léo Saignat, 33076 Bordeaux Cedex, France. [email protected]

PMID: 11427700 PMCID: PMC35482 DOI: 10.1073/pnas.121177998

Abstract

The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agées) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in women, a decrease with age and, among men, a negative correlation between the DHEAS level and mortality at 2 and 4 years. Here, with an 8-year followup in 290 subjects, we show a global decrease of 2.3% per year for men and 3.9% per year for women. However, in approximately 30% of cases, there was an increase of DHEAS. We observed no relationship between the evolution of DHEAS level and functional, psychological, and mental status, possibly because of selection by death. In women, no association was found between mortality and DHEAS level. In men, the relative risk (RR) of death was higher for the lowest levels of DHEAS (RR = 1.9, P = 0.007), with RR = 6.5, P = 0.003 for those under 70 years old, a result indicating heterogeneity of the population. There was an effect of subjective health on mortality that disappeared after adjustment of DHEAS levels, suggesting its relation with these DHEAS levels. Death RR was much higher in smokers with a low DHEAS level than in nonsmokers with high DHEAS (RR = 6.7, P = 0.001). We submit that the involvement of DHEAS is possibly different according to gender, that association between low DHEAS level and mortality only for men under 70 years old possibly reflects heterogeneity of the population, and that DHEAS level is a reliable predictor of death in male smokers.

References

  1. J Clin Endocrinol Metab. 1999 May;84(5):1527-33 - PubMed
  2. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4279-84 - PubMed
  3. J Clin Endocrinol Metab. 2000 May;85(5):1834-40 - PubMed
  4. Arch Intern Med. 2000 Jul 24;160(14):2193-8 - PubMed
  5. Aging (Milano). 2000 Aug;12(4):308-14 - PubMed
  6. J Psychiatr Res. 1975 Nov;12(3):189-98 - PubMed
  7. Am Stat. 1985 Aug;39(3):176-85 - PubMed
  8. J Clin Endocrinol Metab. 1957 Sep;17(9):1051-62 - PubMed
  9. J Clin Endocrinol Metab. 1992 Oct;75(4):1002-4 - PubMed
  10. Recent Prog Horm Res. 1963;19:275-310 - PubMed
  11. Recent Prog Horm Res. 1965;21:411-500 - PubMed
  12. J Clin Endocrinol Metab. 1992 Jan;74(1):139-43 - PubMed
  13. J Steroid Biochem Mol Biol. 1991 Oct;39(4A):529-34 - PubMed
  14. J Am Coll Cardiol. 1990 Nov;16(6):862-70 - PubMed
  15. Stat Med. 1989 Oct;8(10):1255-68 - PubMed
  16. N Engl J Med. 1986 Dec 11;315(24):1519-24 - PubMed
  17. Maturitas. 1986 Dec;8(4):297-307 - PubMed
  18. N Engl J Med. 1988 Jun 30;318(26):1705-9 - PubMed
  19. Am Rev Respir Dis. 1988 May;137(5):1114-8 - PubMed
  20. Gerontologist. 1969 Autumn;9(3):179-86 - PubMed
  21. Gerontologist. 1970 Spring;10(1):20-30 - PubMed
  22. J Gerontol. 1966 Oct;21(4):556-9 - PubMed
  23. J Clin Endocrinol Metab. 1984 Sep;59(3):551-5 - PubMed
  24. J Clin Endocrinol Metab. 1980 Aug;51(2):330-3 - PubMed
  25. J Clin Endocrinol Metab. 1980 Aug;51(2):334-6 - PubMed
  26. J Clin Endocrinol Metab. 1994 Jun;78(6):1360-7 - PubMed
  27. Circulation. 1995 Mar 15;91(6):1757-60 - PubMed
  28. J Clin Endocrinol Metab. 1994 Nov;79(5):1273-6 - PubMed
  29. J Clin Endocrinol Metab. 1994 Nov;79(5):1310-6 - PubMed
  30. Atherosclerosis. 1994 Feb;105(2):191-200 - PubMed
  31. Ann N Y Acad Sci. 1995 Dec 29;774:259-70 - PubMed
  32. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13410-5 - PubMed
  33. J Clin Endocrinol Metab. 1997 Aug;82(8):2403-9 - PubMed
  34. J Clin Endocrinol Metab. 1997 Aug;82(8):2578-85 - PubMed
  35. Br J Urol. 1997 Aug;80(2):201-4 - PubMed
  36. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91 - PubMed
  37. J Lab Clin Med. 1998 Apr;131(4):316-23 - PubMed
  38. Ann Epidemiol. 1998 May;8(4):217-28 - PubMed
  39. J Clin Endocrinol Metab. 1998 Jun;83(6):1928-34 - PubMed
  40. Proc Soc Exp Biol Med. 1998 Jul;218(3):174-91 - PubMed
  41. J Clin Epidemiol. 1998 Oct;51(10):837-41 - PubMed

Substances

MeSH terms

Publication Types