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Neurology. 1976 Feb;26(2):108-16. doi: 10.1212/wnl.26.2.108.

Subacute proximal diabetic neuropathy.

Neurology

I R Williams, R F Mayer

PMID: 943064 DOI: 10.1212/wnl.26.2.108

Abstract

The results of clinical, electrophysiologic, and histologic studies in three patients with a type of diabetic peripheral neuropathy, subacute proximal diabetic neuropathy (diabetic amyotrophy), are presented. On the basis of our findings, we suggest that diabetic amyotrophy is a clinical and pathologic entity separate from mononeuritis multiplex. These patients have a generalized neuropathy, and it is postulated that disordered neuron-axonal metabolism forms the basis for the pathologic and clinical changes. Histochemical changes in the muscle biopsy showed type 1 predominance. We suggest that this phenomenon represents a conversion of surviving fibers of whatever type, to a type 1 oxidative metabolism because of the change in use of these fibers.

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